iPTMnet Report for Q06546 (GABPA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q06546 / GABPA_HUMAN
Protein Name GA-binding protein alpha chain
Gene Name Name: GABPA
Synonyms:E4TF1A;
Organism Homo sapiens (Human)

PRO ID PR:Q06546
DAG View
PRO Name GA-binding protein alpha chain (human)
Definition A GA-binding protein alpha chain that is encoded in the genome of human.
Short Label hGABPA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q06546 (GABPA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Sumoylation PhosphoSitePlus
C22 Methylation IEDB 31844290
S26 Phosphorylation PhosphoSitePlus
C69 Methylation IEDB 31844290
S218 Phosphorylation PhosphoSitePlus
S254 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 34019948, 35254053, 35132862, 31492838, 29485866, 32119511, 29351928
T264 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 34019948, 35254053, 35132862, 31492838, 29485866, 32119511, 29351928
S275 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 34019948, 35254053, 35132862, 31492838, 29485866, 32119511, 29351928
S278 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 34019948, 35254053, 35132862, 31492838, 29485866, 32119511, 29351928
T280 Phosphorylation RLIMS-P 17975830
K292 Ubiquitination PhosphoSitePlus
S303 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S308 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 34019948, 35254053, 35132862, 31492838, 29485866, 32119511, 29351928
S309 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 34019948, 35254053, 35132862, 31492838, 29485866, 32119511, 29351928
S309 Phosphorylation PhosphoSitePlus
K349 Sumoylation PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K364 Acetylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
K373 Acetylation PhosphoSitePlus
K373 Sumoylation PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
R379 Methylation PhosphoSitePlus
Y380 Phosphorylation PhosphoSitePlus
Y381 Phosphorylation PhosphoSitePlus
Y382 Phosphorylation PhosphoSitePlus
C388 Methylation IEDB 31844290
S410 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 34019948, 35254053, 35132862, 31492838, 29485866, 32119511, 29351928
K424 Ubiquitination PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S218 L218 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S303 P303 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S303 L303 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S309 * Biomuta DOID:4159 / skin cancer [ cosmic ]
R379 I379 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R379 G379 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y380 H380 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y381 N381 Biomuta DOID:4159 / skin cancer [ cosmic ]
S410 N410 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K428 N428 Biomuta DOID:1612 / breast cancer [ cosmic ]