iPTMnet Report for Q05D32 (CTDSPL2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q05D32 / CTSL2_HUMAN
Protein Name CTD small phosphatase-like protein 2
Gene Name Name: CTDSPL2
ORFNames:HSPC058,HSPC129;
Organism Homo sapiens (Human)

PRO ID PR:Q05D32
DAG View
PRO Name CTD small phosphatase-like protein 2 (human)
Definition A CTD small phosphatase-like protein 2 that is encoded in the genome of human.
Short Label hCTDSPL2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q05D32 (CTDSPL2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
T17 Phosphorylation PhosphoSitePlus
K26 Acetylation PhosphoSitePlus   UniProt 19608861
K26 Methylation PhosphoSitePlus
Y27 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus   UniProt 23186163
S33 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
K40 Acetylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus
K43 Acetylation PhosphoSitePlus
K43 Sumoylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus   UniProt 23186163
K53 Ubiquitination PhosphoSitePlus
K57 Acetylation PhosphoSitePlus   UniProt 19608861
S59 Phosphorylation PhosphoSitePlus
T60 Phosphorylation PhosphoSitePlus
S69 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus   UniProt 18669648
T86 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
K95 Ubiquitination PhosphoSitePlus
S104 Phosphorylation IEDB   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...27920218, 18669648, 20068231
S112 Phosphorylation PhosphoSitePlus
Y113 Phosphorylation PhosphoSitePlus
T116 Phosphorylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332, 20068231
S146 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
T160 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...19690332, 20068231
K275 Sumoylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
R450 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y27 Phosphorylation HPRD 17081983
S28 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S33 Phosphorylation HPRD 17081983
S50 Phosphorylation HPRD 20068231
S51 Phosphorylation HPRD 18669648, 17081983, 20068231
T84 Phosphorylation HPRD 18669648
S85 Phosphorylation HPRD 18669648, 20068231
T86 Phosphorylation HPRD 18669648, 19664995, 20068231
S104 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S134 Phosphorylation HPRD 18691976, 20068231
S161 Phosphorylation HPRD 18669648
S165 Phosphorylation HPRD 19413330, 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S36 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S42 L42 Biomuta DOID:4159 / skin cancer [ cosmic ]
S50 F50 Biomuta [ cosmic ]
S59 G59 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S131 F131 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S153 L153 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T160 M160 Biomuta DOID:363 / uterine cancer [ icgc ]
S163 L163 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S165 Y165 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R450 L450 Biomuta DOID:1324 / lung cancer [ cosmic ]
R450 * Biomuta DOID:1324 / lung cancer [ cosmic ]