iPTMnet Report for Q05682 (CALD1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q05682 / CALD1_HUMAN
Protein Name Caldesmon
Gene Name Name: CALD1
Synonyms:CAD,CDM;
Organism Homo sapiens (Human)

PRO ID PR:Q05682
DAG View
PRO Name caldesmon (human)
Definition A caldesmon that is encoded in the genome of human.
Short Label hCALD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q05682 (CALD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R12 Phosphorylation UniProt 18669648, 20068231
E21 Phosphorylation UniProt 20068231
Y27 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S58 Phosphorylation PhosphoSitePlus
S73 Phosphorylation Q15746 (MYLK) neXtProt   PhosphoSitePlus 20536391
T83 Phosphorylation PhosphoSitePlus
T84 Phosphorylation PhosphoSitePlus
T86 Phosphorylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
T124 Phosphorylation PhosphoSitePlus
T126 O-Glycosylation GlyGen 23301498, 30379171, 34019948, ...33465208, 35254053
S129 Phosphorylation PhosphoSitePlus   UniProt 24275569
S131 Phosphorylation PhosphoSitePlus
T141 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
Y160 Phosphorylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
Y172 Phosphorylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
E196 Phosphorylation UniProt 20068231, 21406692, 17081983, ...24275569
K197 Sumoylation PhosphoSitePlus
S202 Phosphorylation PhosphoSitePlus   UniProt 20068231, 21406692, 17081983, ...24275569
S219 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
T402 Phosphorylation PhosphoSitePlus
K427 Acetylation PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
S493 Phosphorylation PhosphoSitePlus
T506 Phosphorylation PhosphoSitePlus
T509 Phosphorylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
S518 O-Glycosylation GlyGen 23301498, 30379171, 34019948, ...33465208, 35254053
S518 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
T521 Phosphorylation PhosphoSitePlus
K534 Acetylation PhosphoSitePlus
T546 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
K569 Ubiquitination PhosphoSitePlus
S628 Phosphorylation PhosphoSitePlus
T638 Phosphorylation phospho.ELM 12613668
K640 Acetylation PhosphoSitePlus
S642 Phosphorylation PhosphoSitePlus
S643 Phosphorylation P17252 (PRKCA) , Q9UQM7 (CAMK2A) phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 18669648, 2170388, ...8182108
K645 Acetylation PhosphoSitePlus
K645 Sumoylation PhosphoSitePlus
K655 Acetylation PhosphoSitePlus
K655 Ubiquitination PhosphoSitePlus
S656 Phosphorylation Q9UQM7 (CAMK2A) , P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   Signor   UniProt 18669648, 23186163, 2170388, ...8182108
S660 Phosphorylation PhosphoSitePlus
S661 Phosphorylation PhosphoSitePlus
T666 Phosphorylation Q15746 (MYLK) neXtProt   PhosphoSitePlus 20536391
S673 Phosphorylation PhosphoSitePlus
K674 Ubiquitination PhosphoSitePlus
S677 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 8182108
Y682 Phosphorylation PhosphoSitePlus
S684 Phosphorylation PhosphoSitePlus
K690 Ubiquitination PhosphoSitePlus
S691 Phosphorylation PhosphoSitePlus
T695 Phosphorylation PhosphoSitePlus
S700 Phosphorylation Q15746 (MYLK) neXtProt 20536391
K713 Ubiquitination PhosphoSitePlus
S714 Phosphorylation O75914 (PAK3) , Q13177 (PAK2) PhosphoSitePlus   Signor 20858431, 16800003
K718 Ubiquitination PhosphoSitePlus
S723 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S724 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 12613668, 20068231
T726 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T730 Phosphorylation P24941 (CDK2) , Q00534 (CDK6) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18847512, ...18669648, 12613668, 16115893, 20068231, 17924679
K733 Acetylation PhosphoSitePlus
K733 Ubiquitination PhosphoSitePlus
T735 Phosphorylation Q15746 (MYLK) neXtProt   phospho.ELM   PhosphoSitePlus 18669648, 20536391
S744 O-Glycosylation GlyGen 31373491
S744 Phosphorylation Q15746 (MYLK) , Q13177 (PAK2) , O75914 (PAK3) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 20858431, 12613668, 20536391, ...16800003
K752 Acetylation PhosphoSitePlus
T753 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...24275569
K758 Acetylation PhosphoSitePlus
S759 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17287340, 11983427, 18669648, ...10514499, 12613668, 23186163
S765 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S773 Phosphorylation PhosphoSitePlus
K775 Methylation PhosphoSitePlus
K775 Ubiquitination PhosphoSitePlus
S783 O-Glycosylation GlyGen 23301498, 30379171, 34019948, ...33465208, 35254053
S783 Phosphorylation PhosphoSitePlus
T788 Phosphorylation PhosphoSitePlus
S789 Phosphorylation P27361 (MAPK3) , Q00534 (CDK6) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22197205, 21406692, 16115893, ...21738699, 10751321, 18669648, 10514499, 16627824
T791 O-Glycosylation GlyGen 33465208
T791 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y27 Phosphorylation HPRD 17081983
S202 Phosphorylation HPRD 20166139, 20068231
S493 Phosphorylation HPRD 20166139
S511 Phosphorylation HPRD 18212344
S518 Phosphorylation HPRD 17287340
T546 Phosphorylation HPRD 18212344
T638 Phosphorylation P06493 (CDK1) HPRD 12613668
S643 Phosphorylation HPRD 20166139, 1601129, 18669648
S656 Phosphorylation HPRD 20166139, 1601129, 18669648, ...18212344, 17924679
S684 Phosphorylation HPRD 18212344
S723 Phosphorylation HPRD 18669648, 19664995, 20068231, ...17924679
S724 Phosphorylation P06493 (CDK1) HPRD 19413330, 19664995, 18669648, ...12613668, 19415658, 20068231, 17924679
T726 Phosphorylation HPRD 19413330, 18669648, 19664994, ...19664995, 20068231
T730 Phosphorylation P06493 (CDK1) HPRD 19413330, 19664995, 18669648, ...12613668, 19415658, 20068231, 17924679
T735 Phosphorylation HPRD 18669648
S744 Phosphorylation P06493 (CDK1) HPRD 12613668
T753 Phosphorylation HPRD 18669648, 20068231
S759 Phosphorylation P06493 (CDK1) HPRD 19651622, 18669648, 12613668, ...17287340, 20068231
S765 Phosphorylation HPRD 19651622, 17287340
S783 Phosphorylation HPRD 1601129
T788 Phosphorylation HPRD 20068231
S789 Phosphorylation HPRD 1601129, 18669648, 18212344, ...20068231, 19664995
Site PTM Type PTM Enzyme Score Source PMID
S202 Phosphorylation PhosphoSitePlus
T277 Phosphorylation phospho.ELM 18669648
Y453 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus
S7 Phosphorylation HPRD   PhosphoSitePlus 20068231
S12 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
S17 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y21 Phosphorylation HPRD   PhosphoSitePlus 20068231
S196 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983, 20068231, ...18212344
S258 Phosphorylation HPRD 20166139
T265 Phosphorylation phospho.ELM 18669648
S276 Phosphorylation HPRD 18212344
S283 Phosphorylation HPRD 17287340
T311 Phosphorylation HPRD 18212344
T403 Phosphorylation P06493 (CDK1) HPRD 12613668
S408 Phosphorylation HPRD 20166139, 1601129, 18669648
S421 Phosphorylation HPRD 20166139, 1601129, 18669648, ...18212344, 17924679
S449 Phosphorylation HPRD 18212344
S488 Phosphorylation HPRD 18669648, 19664995, 20068231, ...17924679
S489 Phosphorylation P06493 (CDK1) HPRD 19413330, 19664995, 18669648, ...12613668, 19415658, 20068231, 17924679
T491 Phosphorylation HPRD 19413330, 18669648, 19664994, ...19664995, 20068231
T495 Phosphorylation P06493 (CDK1) HPRD 19413330, 19664995, 18669648, ...12613668, 19415658, 20068231, 17924679
T500 Phosphorylation HPRD 18669648
S509 Phosphorylation P06493 (CDK1) HPRD 12613668
T518 Phosphorylation HPRD 18669648, 20068231
S524 Phosphorylation P06493 (CDK1) HPRD 19651622, 18669648, 12613668, ...17287340, 20068231
S530 Phosphorylation HPRD 19651622, 17287340
S548 Phosphorylation HPRD 1601129
T553 Phosphorylation HPRD 20068231
S554 Phosphorylation HPRD 1601129, 18669648, 18212344, ...20068231, 19664995
Site PTM Type PTM Enzyme Score Source PMID
Y27 Phosphorylation HPRD 17081983
R200 Methylation PhosphoSitePlus
S202 Phosphorylation HPRD   PhosphoSitePlus 18212344, 19664995, 19651622, ...20166139, 20068231, 17081983
K209 Sumoylation PhosphoSitePlus
S238 Phosphorylation HPRD 20166139
S256 Phosphorylation HPRD 18212344
S263 Phosphorylation HPRD 17287340
T291 Phosphorylation HPRD 18212344
T383 Phosphorylation P06493 (CDK1) HPRD 12613668
S388 Phosphorylation HPRD 20166139, 1601129, 18669648
S401 Phosphorylation HPRD 20166139, 1601129, 18669648, ...18212344, 17924679
S429 Phosphorylation HPRD 18212344
S468 Phosphorylation HPRD 18669648, 19664995, 20068231, ...17924679
S469 Phosphorylation P06493 (CDK1) HPRD 19413330, 19664995, 18669648, ...12613668, 19415658, 20068231, 17924679
T471 Phosphorylation HPRD 19413330, 18669648, 19664994, ...19664995, 20068231
T475 Phosphorylation P06493 (CDK1) HPRD 19413330, 19664995, 18669648, ...12613668, 19415658, 20068231, 17924679
T480 Phosphorylation HPRD 18669648
S489 Phosphorylation P06493 (CDK1) HPRD 12613668
T498 Phosphorylation HPRD 18669648, 20068231
S504 Phosphorylation P06493 (CDK1) HPRD 19651622, 18669648, 12613668, ...17287340, 20068231
S510 Phosphorylation HPRD 19651622, 17287340
S528 Phosphorylation HPRD 1601129
T533 Phosphorylation HPRD 20068231
S534 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD   PhosphoSitePlus 18212344, 19664995, 18669648, ...26079947, 1601129, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD 20068231
S12 Phosphorylation HPRD 18669648, 20068231
S17 Phosphorylation HPRD 20068231
Y21 Phosphorylation HPRD 20068231
S196 Phosphorylation HPRD 18212344, 19664995, 19651622, ...20166139, 20068231, 17081983
S232 Phosphorylation HPRD 20166139
S250 Phosphorylation HPRD 18212344
S257 Phosphorylation HPRD 17287340
T285 Phosphorylation HPRD 18212344
T377 Phosphorylation P06493 (CDK1) HPRD 12613668
S382 Phosphorylation HPRD 20166139, 1601129, 18669648
S395 Phosphorylation HPRD 20166139, 1601129, 18669648, ...18212344, 17924679
S423 Phosphorylation HPRD 18212344
S462 Phosphorylation HPRD 18669648, 19664995, 20068231, ...17924679
S463 Phosphorylation P06493 (CDK1) HPRD 19413330, 19664995, 18669648, ...12613668, 19415658, 20068231, 17924679
T465 Phosphorylation HPRD 19413330, 18669648, 19664994, ...19664995, 20068231
T469 Phosphorylation P06493 (CDK1) HPRD 19413330, 19664995, 18669648, ...12613668, 19415658, 20068231, 17924679
T474 Phosphorylation HPRD 18669648
S483 Phosphorylation P06493 (CDK1) HPRD 12613668
T492 Phosphorylation HPRD 18669648, 20068231
S498 Phosphorylation P06493 (CDK1) HPRD 19651622, 18669648, 12613668, ...17287340, 20068231
S504 Phosphorylation HPRD 19651622, 17287340
S522 Phosphorylation HPRD 1601129
T527 Phosphorylation HPRD 20068231
S528 Phosphorylation HPRD 1601129, 18669648, 18212344, ...20068231, 19664995
Site PTM Type PTM Enzyme Score Source PMID
Y27 Phosphorylation HPRD 17081983
S202 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983, 20068231, ...18212344
S264 Phosphorylation HPRD 20166139
S282 Phosphorylation HPRD 18212344
S289 Phosphorylation HPRD 17287340
T317 Phosphorylation HPRD 18212344
T409 Phosphorylation P06493 (CDK1) HPRD 12613668
S414 Phosphorylation HPRD 20166139, 1601129, 18669648
S427 Phosphorylation HPRD   PhosphoSitePlus 18212344, 18669648, 20166139, ...1601129, 17924679
S431 Phosphorylation PhosphoSitePlus
S454 Phosphorylation HPRD 18212344
S493 Phosphorylation HPRD 18669648, 19664995, 20068231, ...17924679
S494 Phosphorylation P06493 (CDK1) HPRD 19413330, 19664995, 18669648, ...12613668, 19415658, 20068231, 17924679
T496 Phosphorylation HPRD 19413330, 18669648, 19664994, ...19664995, 20068231
T500 Phosphorylation P06493 (CDK1) HPRD 19413330, 19664995, 18669648, ...12613668, 19415658, 20068231, 17924679
T505 Phosphorylation HPRD 18669648
S514 Phosphorylation P06493 (CDK1) HPRD 12613668
T523 Phosphorylation HPRD 18669648, 20068231
S529 Phosphorylation P06493 (CDK1) HPRD 19651622, 18669648, 12613668, ...17287340, 20068231
S535 Phosphorylation HPRD 19651622, 17287340
S553 Phosphorylation HPRD 1601129
T558 Phosphorylation HPRD 20068231
S559 Phosphorylation HPRD 1601129, 18669648, 18212344, ...20068231, 19664995


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
E21 K21 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S58 F58 Biomuta DOID:4159 / skin cancer [ cosmic ]
K119 R119 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S129 R129 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T141 I141 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T141 A141 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y172 H172 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y172 C172 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
R200 Q200 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R200 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K209 E209 Biomuta DOID:3571 / liver cancer [ cosmic ]
S232 L232 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S238 L238 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S257 I257 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S258 L258 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S263 I263 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S264 L264 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S283 I283 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S289 I289 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S382 Y382 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S382 F382 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S388 Y388 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S388 F388 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T402 A402 Biomuta DOID:363 / uterine cancer [ icgc ]
S408 Y408 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S408 F408 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S414 Y414 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S414 F414 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S431 R431 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S462 * Biomuta DOID:363 / uterine cancer [ cosmic ]
T465 I465 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S468 * Biomuta DOID:363 / uterine cancer [ cosmic ]
T471 I471 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S488 * Biomuta DOID:363 / uterine cancer [ cosmic ]
T491 I491 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S493 L493 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S493 * Biomuta DOID:363 / uterine cancer [ cosmic ]
T496 I496 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S504 F504 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S504 Y504 Biomuta DOID:363 / uterine cancer [ icgc ]
T506 A506 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S510 F510 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S510 Y510 Biomuta DOID:363 / uterine cancer [ icgc ]
S518 I518 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S530 Y530 Biomuta DOID:363 / uterine cancer [ icgc ]
S530 F530 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S535 Y535 Biomuta DOID:363 / uterine cancer [ icgc ]
S535 F535 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S643 Y643 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S643 F643 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S660 R660 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S661 I661 Biomuta DOID:1324 / lung cancer [ cosmic ]
S673 C673 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K674 N674 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K674 R674 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S677 R677 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S677 N677 Biomuta DOID:363 / uterine cancer [ cosmic ]
K690 E690 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S723 * Biomuta DOID:363 / uterine cancer [ cosmic ]
T726 I726 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K733 N733 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S765 F765 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S765 Y765 Biomuta DOID:363 / uterine cancer [ icgc ]
S773 T773 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]