iPTMnet Report for Q05209 (PTPN12)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q05209 / PTN12_HUMAN
Protein Name Tyrosine-protein phosphatase non-receptor type 12
Gene Name Name: PTPN12
Organism Homo sapiens (Human)

PRO ID PR:Q05209
DAG View
PRO Name tyrosine-protein phosphatase non-receptor type 12 (human)
Definition A tyrosine-protein phosphatase non-receptor type 12 that is encoded in the genome of human.
Short Label hPTPN12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q05209 (PTPN12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378, 12665801, 22223895
S19 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 32541467, 28842430, ...20068231, 27134172
S39 Phosphorylation P17612 (PRKACA) , P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 7520867, 7909431
T40 Phosphorylation PhosphoSitePlus
Y64 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
Y88 Phosphorylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
Y301 Phosphorylation PhosphoSitePlus
T318 Phosphorylation PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus
S332 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569
S342 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
S398 Phosphorylation PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
S435 Phosphorylation P17612 (PRKACA) , P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 7909431, 21406692, 23186163, ...32501498, 18669648, 7520867, 20068231
S449 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
T454 Phosphorylation PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
S468 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T490 Phosphorylation PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
S494 Phosphorylation PhosphoSitePlus
S499 Phosphorylation RLIMS-P 32501498
T501 O-Glycosylation GlyGen 32938750
S507 Phosphorylation PhosphoSitePlus
T509 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S514 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S517 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T519 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 32501498, 18669648
Y560 Phosphorylation IEDB 32387766
T565 Phosphorylation PhosphoSitePlus
S567 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T569 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 32501498, 18669648, 18088087
S571 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 18669648, 21876001, ...18088087
T573 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T578 Phosphorylation PhosphoSitePlus
T587 Phosphorylation phospho.ELM 18669648
S588 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T593 Phosphorylation PhosphoSitePlus
S596 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S603 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18088087, 21406692, ...17081983
S606 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 18088087, 17081983, ...18669648, 24275569, 32501498, 23186163
S608 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S613 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T622 O-Glycosylation GlyGen 23301498, 34019948, 35254053
T622 Phosphorylation PhosphoSitePlus
S625 O-Glycosylation GlyGen 23301498, 34019948, 32938750, ...35254053
T626 O-Glycosylation GlyGen 23301498, 34019948, 35254053
T630 O-Glycosylation GlyGen 23301498, 34019948, 32938750, ...35254053
S636 Phosphorylation PhosphoSitePlus
S649 Phosphorylation PhosphoSitePlus
S661 Phosphorylation PhosphoSitePlus
S670 Phosphorylation PhosphoSitePlus
S673 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18088087, 16964243, ...24275569, 23186163, 20068231
T681 Phosphorylation PhosphoSitePlus
S689 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
T693 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
S708 Phosphorylation PhosphoSitePlus
S713 Phosphorylation PhosphoSitePlus
S719 Phosphorylation PhosphoSitePlus
Y733 Phosphorylation PhosphoSitePlus
T780 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation HPRD 19651622, 20068231
S39 Phosphorylation P17612 (PRKACA) , P17252 (PRKCA) HPRD 7520867
Y42 Phosphorylation HPRD 20068231
S324 Phosphorylation HPRD 20058876
S332 Phosphorylation HPRD 17081983
S435 Phosphorylation P17252 (PRKCA) , P17612 (PRKACA) HPRD 19651622, 18767875, 18669648, ...7520867, 20068231
S449 Phosphorylation HPRD 20068231
T454 Phosphorylation HPRD 18212344
S468 Phosphorylation HPRD 18669648
T509 Phosphorylation HPRD 18669648, 20230923
S514 Phosphorylation HPRD 18669648
S517 Phosphorylation HPRD 18669648
T519 Phosphorylation HPRD 18669648, 16964243
S567 Phosphorylation HPRD 18669648
T569 Phosphorylation HPRD 19651622, 18669648, 18088087, ...20068231
S571 Phosphorylation HPRD 19651622, 18669648, 18088087, ...20068231
T573 Phosphorylation HPRD 18669648
T587 Phosphorylation HPRD 18669648
S588 Phosphorylation HPRD 18669648
T593 Phosphorylation HPRD 17081983
S596 Phosphorylation HPRD 19651622, 18669648, 17081983
T598 Phosphorylation HPRD 17081983
S603 Phosphorylation HPRD 18088087, 17081983, 18452278, ...19651622, 18669648, 19415658, 20068231
S606 Phosphorylation HPRD 17322306, 18088087, 18452278, ...19651622, 18669648, 19415658, 20068231
S608 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
S613 Phosphorylation HPRD 19651622, 18669648, 17081983
S670 Phosphorylation HPRD 19651622, 18767875, 20058876, ...20068231
S673 Phosphorylation HPRD 17322306, 18088087, 16964243, ...18767875, 19664994, 19651622, 20058876, 18707149, 20068231
S689 Phosphorylation HPRD 18669648, 17081983
T693 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y64 C64 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y88 F88 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K95 N95 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
Y301 F301 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S397 L397 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T454 I454 Biomuta DOID:1324 / lung cancer [ cosmic ]
S494 F494 Biomuta DOID:4159 / skin cancer [ cosmic ]
T573 A573 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T598 I598 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S625 L625 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S661 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S661 P661 Biomuta DOID:1319 / brain cancer [ cosmic ]
T681 I681 Biomuta DOID:4159 / skin cancer [ cosmic ]
T693 A693 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T693 I693 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T693 S693 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T693 P693 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T780 A780 Biomuta DOID:184 / bone cancer [ cosmic ]