iPTMnet Report Q04727 TLE4

Protein Information

UniProt AC / UniProt ID	Q04727 / TLE4_HUMAN
Protein Name	Transducin-like enhancer protein 4
Gene Name	Name: TLE4 Synonyms:GRG4,KIAA1261;
Organism	Homo sapiens (Human)

PRO ID	PR:Q04727 DAG View
PRO Name	transducin-like enhancer protein 4 (human)
Definition	A transducin-like enhancer protein 4 that is encoded in the genome of human.
Short Label	hTLE4
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q04727 (TLE4) as Substrate

Condensed View

Site	PTM Type	Score	Source	PMID
	Ubiquitination	score1	PRO
R13	Methylation	score1	PhosphoSitePlus
K36	Ubiquitination	score1	PhosphoSitePlus
K60	Ubiquitination	score1	PhosphoSitePlus
K89	Ubiquitination	score1	PhosphoSitePlus
S206	Phosphorylation	score1	PhosphoSitePlus
S208	O-Glycosylation	score1	GlyGen	30379171
S208	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163, 24275569
S212	O-Glycosylation	score1	GlyGen	35138101, 34019948, 30379171, ...32574038, 30059200, 35254053, 35132862, 21606357, 30620550, 31492838, 29485866, 29351928, 28657654, 29237092
S212	Phosphorylation	score1	PhosphoSitePlus
S222	Phosphorylation	score1	PhosphoSitePlus
Y225	Phosphorylation	score1	PhosphoSitePlus
S226	Phosphorylation	score1	PhosphoSitePlus
S227	Phosphorylation	score1	PhosphoSitePlus
K237	Acetylation	score2	PhosphoSitePlus UniProt	19608861
Y243	Phosphorylation	score1	PhosphoSitePlus
S245	Phosphorylation	score1	PhosphoSitePlus
S250	Phosphorylation	score2	PhosphoSitePlus UniProt	17081983
S259	Phosphorylation	score1	PhosphoSitePlus
S264	Phosphorylation	score1	PhosphoSitePlus
S265	Phosphorylation	score1	PhosphoSitePlus
S269	Phosphorylation	score2	PhosphoSitePlus UniProt	17081983
S273	Phosphorylation	score1	PhosphoSitePlus
K281	Acetylation	score2	PhosphoSitePlus UniProt	19608861
T282	Phosphorylation	score1	PhosphoSitePlus
S292	Phosphorylation	score2	PhosphoSitePlus UniProt	21406692, 23186163, 19690332
S295	O-Glycosylation	score1	GlyGen	35138101, 34019948, 30379171, ...32574038, 30059200, 35254053, 35132862, 21606357, 30620550, 31492838, 29485866, 29351928, 28657654, 29237092
S295	Phosphorylation	score1	PhosphoSitePlus
S299	Phosphorylation	score1	PhosphoSitePlus
T302	Phosphorylation	score1	PhosphoSitePlus
S305	O-Glycosylation	score1	GlyGen	30620550
S305	Phosphorylation	score1	PhosphoSitePlus
K308	Acetylation	score1	PhosphoSitePlus
T317	O-Glycosylation	score1	GlyGen	32574038
T317	Phosphorylation	score1	PhosphoSitePlus
T318	O-Glycosylation	score1	GlyGen	35138101, 34019948, 30379171, ...32574038, 30059200, 35254053, 35132862, 21606357, 30620550, 31492838, 29485866, 29351928, 28657654, 29237092
T318	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	18669648
S321	O-Glycosylation	score1	GlyGen	35138101, 34019948, 30379171, ...32574038, 30059200, 35254053, 35132862, 21606357, 30620550, 31492838, 29485866, 29351928, 28657654, 29237092
S321	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	18669648
K322	Acetylation	score1	PhosphoSitePlus
S323	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	18669648
T325	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	18669648
T327	Phosphorylation	score1	PhosphoSitePlus
T330	O-Glycosylation	score1	GlyGen	34846842, 35138101, 35254053, ...30379171, 32574038, 32938750, 34019948, 30059200, 35132862, 21606357, 30620550, 31492838, 29485866, 29351928, 28657654, 29237092
T334	O-Glycosylation	score1	GlyGen	35138101, 34019948, 30379171, ...32574038, 30059200, 35254053, 35132862, 21606357, 30620550, 31492838, 29485866, 29351928, 28657654, 29237092
T334	Phosphorylation	score1	PhosphoSitePlus
S337	O-Glycosylation	score1	GlyGen	35138101, 34019948, 30379171, ...32574038, 30059200, 35254053, 35132862, 21606357, 30620550, 31492838, 29485866, 29351928, 28657654, 29237092
T340	O-Glycosylation	score1	GlyGen	35138101, 34019948, 30379171, ...32574038, 30059200, 35254053, 35132862, 21606357, 30620550, 31492838, 29485866, 29351928, 28657654, 29237092
S358	O-Glycosylation	score1	GlyGen	35138101, 34019948, 30379171, ...32574038, 30059200, 35254053, 35132862, 21606357, 30620550, 31492838, 29485866, 29351928, 28657654, 29237092
S359	O-Glycosylation	score1	GlyGen	35138101, 34019948, 30379171, ...32574038, 30059200, 35254053, 35132862, 21606357, 30620550, 31492838, 29485866, 29351928, 28657654, 29237092
R431	Methylation	score1	PhosphoSitePlus
K507	Ubiquitination	score1	PhosphoSitePlus
R644	Methylation	score1	PhosphoSitePlus
Y695	Phosphorylation	score1	PhosphoSitePlus
S702	Phosphorylation	score1	PhosphoSitePlus
S706	Phosphorylation	score1	PhosphoSitePlus
K721	Acetylation	score1	PhosphoSitePlus
K721	Ubiquitination	score1	PhosphoSitePlus
K764	Ubiquitination	score1	PhosphoSitePlus
K765	Sumoylation	score1	PhosphoSitePlus

Site	PTM Type	Score	Source	PMID
S206	Phosphorylation	score0	HPRD	19413330, 19651622
S208	Phosphorylation	score0	HPRD	19413330, 20058876, 18767875, ...19664994, 19664995, 19651622
Y243	Phosphorylation	score0	HPRD	19413330
S245	Phosphorylation	score0	HPRD	19413330
S250	Phosphorylation	score0	HPRD	19651622, 17081983
S264	Phosphorylation	score0	HPRD	19651622, 17081983
S265	Phosphorylation	score0	HPRD	19413330, 19651622, 17081983
S269	Phosphorylation	score0	HPRD	17081983
S273	Phosphorylation	score0	HPRD	19651622
S292	Phosphorylation	score0	HPRD	19413330
S305	Phosphorylation	score0	HPRD	19413330
T318	Phosphorylation	score0	HPRD	18669648
S321	Phosphorylation	score0	HPRD	18669648
S323	Phosphorylation	score0	HPRD	18669648
T325	Phosphorylation	score0	HPRD	18669648

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000049466 (hTLE4/UbiqLys+)	ub		PRO

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
R13	K13	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S206	L206	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S226	F226	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
K237	N237	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
Y243	S243	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S265	F265	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S273	F273	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S273	C273	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S273	P273	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S295	C295	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
T317	A317	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S321	*	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
K322	N322	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S359	G359	Biomuta	DOID:4362 / cervical cancer [ cosmic, icgc ]
R431	C431	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
R431	H431	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ]
R431	L431	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
R644	M644	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S706	L706	Biomuta	DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
K764	N764	Biomuta	DOID:1324 / lung cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q04727 (TLE4)

Protein Information

Interactive Sequence View

Q04727 (TLE4) as Substrate

Proteoforms

PTM sites affected in variants