iPTMnet Report for Q04609 (FOLH1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q04609 / FOLH1_HUMAN
Protein Name Glutamate carboxypeptidase 2
Gene Name Name: FOLH1
Synonyms:FOLH,NAALAD1,PSM,PSMA;ORFNames:GIG27;
Organism Homo sapiens (Human)

PRO ID PR:Q04609
DAG View
PRO Name glutamate carboxypeptidase 2 (human)
Definition A glutamate carboxypeptidase 2 that is encoded in the genome of human.
Short Label hFOLH1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q04609 (FOLH1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
N51 N-Glycosylation GlyGen   UniProt 15152093
N76 N-Glycosylation GlyGen   UniProt 15152093, 19301871, 19053759, ...17372356, 16467855, 17567119, 12754519, 18234225
N121 N-Glycosylation GlyGen   UniProt 15152093, 19301871, 17567119, ...17372356, 16467855, 19053759, 18234225
N140 N-Glycosylation GlyGen   UniProt 15152093, 19301871, 17567119, ...17372356, 16467855, 19053759, 18234225
N153 N-Glycosylation GlyGen   UniProt 15152093
N195 N-Glycosylation GlyGen   UniProt 15152093, 19301871, 17567119, ...17372356, 16467855, 19053759, 18234225
S312 Phosphorylation PhosphoSitePlus
N336 N-Glycosylation GlyGen   UniProt 12754519, 15152093
N459 N-Glycosylation GlyGen   UniProt 15152093, 19301871, 19053759, ...17372356, 16467855, 17567119, 12754519, 18234225
N476 N-Glycosylation GlyGen   UniProt 15152093, 19301871, 19053759, ...17372356, 16467855, 17567119, 12754519, 18234225
S532 Phosphorylation PhosphoSitePlus
Y549 Phosphorylation PhosphoSitePlus
N638 N-Glycosylation GlyGen   UniProt 15152093, 19301871, 19053759, ...17372356, 16467855, 17567119, 12754519, 18234225


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S10 L10 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N121 S121 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
N153 S153 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
N195 S195 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
N459 K459 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]