iPTMnet Report for Q03252 (LMNB2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q03252 / LMNB2_HUMAN
Protein Name Lamin-B2 precursor
Gene Name Name: LMNB2
Synonyms:LMN2;
Organism Homo sapiens (Human)

PRO ID PR:Q03252
DAG View
PRO Name lamin-B2 (human)
Definition A lamin-B2 that is encoded in the genome of human.
Short Label hLMNB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q03252 (LMNB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus
T20 O-Glycosylation GlyGen 33214551, 34725712, 34019948, ...32119511, 28510447, 33465208
T23 Phosphorylation PhosphoSitePlus   UniProt 23186163
R28 Methylation PhosphoSitePlus
T34 Phosphorylation PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...24275569, 19690332, 20068231
S37 Phosphorylation P24941 (CDK2) PhosphoSitePlus   UniProt 18669648, 23186163, 18847512
T39 O-Glycosylation GlyGen 33465208
T39 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S42 Phosphorylation PhosphoSitePlus
K47 Acetylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
R56 Methylation PhosphoSitePlus
Y60 Phosphorylation PhosphoSitePlus
R73 Methylation PhosphoSitePlus
K77 Acetylation PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
K81 Acetylation PhosphoSitePlus   UniProt 19608861
K81 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
Y96 Phosphorylation PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
K150 Acetylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
K170 Acetylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
R171 Methylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
K186 Acetylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K195 Acetylation PhosphoSitePlus
K200 Acetylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
R211 Methylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
S224 O-Glycosylation GlyGen 33214551, 34725712, 34019948, ...32119511, 28510447, 33465208
S224 Phosphorylation PhosphoSitePlus
T233 O-Glycosylation GlyGen 33465208
S246 Phosphorylation PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
R264 Methylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
R272 Methylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
Y282 Phosphorylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K290 Acetylation PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
K298 Acetylation PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
S316 Phosphorylation IEDB   PhosphoSitePlus   UniProt 32387766, 23186163
S318 Phosphorylation PhosphoSitePlus
Y319 Phosphorylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
R334 Methylation PhosphoSitePlus
K348 Acetylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
Y374 Phosphorylation PhosphoSitePlus
K393 Acetylation PhosphoSitePlus
K393 Sumoylation PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
R401 Methylation PhosphoSitePlus
K403 Acetylation PhosphoSitePlus
K403 Sumoylation PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
S409 Phosphorylation PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
T413 Phosphorylation PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
T418 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus   UniProt 21406692
S421 Phosphorylation PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus   UniProt 18669648, 21406692
S424 Phosphorylation PhosphoSitePlus   UniProt 18669648, 21406692
L425 Phosphorylation PhosphoSitePlus
S426 Phosphorylation PhosphoSitePlus   UniProt 18669648, 21406692
T428 Phosphorylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
K494 Ubiquitination PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y515 Phosphorylation PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
T518 Phosphorylation PhosphoSitePlus
K520 Acetylation PhosphoSitePlus
K520 Ubiquitination PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
T556 Phosphorylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R73 W73 Biomuta [ cosmic ]
S79 T79 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S154 F154 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K170 E170 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K170 T170 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R171 H171 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K186 E186 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R211 C211 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S246 N246 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R264 Q264 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
Y282 F282 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
Y282 C282 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K290 N290 Biomuta DOID:1319 / brain cancer [ icgc ]
K351 N351 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S415 * Biomuta DOID:1612 / breast cancer [ cosmic ]
T418 I418 Biomuta DOID:3571 / liver cancer [ icgc ]
S492 P492 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T518 M518 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S541 G541 Biomuta DOID:3571 / liver cancer [ cosmic ]
S541 C541 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]