iPTMnet Report for Q02818 (NUCB1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q02818 / NUCB1_HUMAN
Protein Name Nucleobindin-1 precursor
Gene Name Name: NUCB1
Synonyms:NUC;
Organism Homo sapiens (Human)

PRO ID PR:Q02818
DAG View
PRO Name nucleobindin-1 (human)
Definition A nucleobindin-1 that is encoded in the genome of human.
Short Label hNUCB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q02818 (NUCB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation HPRD   PhosphoSitePlus 20068231
T39 O-Glycosylation GlyGen   PhosphoSitePlus 30459171, 25813380, 34019948, ...29351928, 35132862, 22661428, 31492838, 23584533, 28510447, 33465208, 30059200
T42 O-Glycosylation GlyGen   PhosphoSitePlus 30459171, 25813380, 34019948, ...29351928, 35132862, 22661428, 31492838, 23584533, 28510447, 33465208, 29237092, 30059200
S44 O-Glycosylation GlyGen   PhosphoSitePlus 28510447, 30459171, 25813380, ...34019948, 30059200, 35132862, 22661428, 31492838, 23584533, 29351928, 33465208
S44 Phosphorylation PhosphoSitePlus
T47 O-Glycosylation GlyGen   PhosphoSitePlus 25813380, 34019948, 29351928, ...35132862, 22661428, 31492838, 23584533, 28510447, 33465208, 30059200
T47 Phosphorylation PhosphoSitePlus
Y50 O-Glycosylation GlyGen 23584533, 23399548, 25813380
Y51 O-Glycosylation GlyGen 23584533, 25813380
Y54 O-Glycosylation GlyGen 25813380
T64 Phosphorylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
S86 Phosphorylation HPRD   PhosphoSitePlus   UniProt 26091039, 20068231
S93 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S93 Phosphorylation HPRD   PhosphoSitePlus 20068231
T148 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T148 Phosphorylation PhosphoSitePlus   UniProt 26091039, 24275569
T160 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T162 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
Y168 O-Glycosylation GlyGen 23584533, 25813380
Y168 Phosphorylation PhosphoSitePlus
K177 Acetylation PhosphoSitePlus
Y179 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
Y190 O-Glycosylation GlyGen 25813380
Y190 Phosphorylation PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus
S224 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S224 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332
K229 Ubiquitination PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
R310 Methylation PhosphoSitePlus
T313 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S320 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S320 Phosphorylation PhosphoSitePlus
T321 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T335 Phosphorylation PhosphoSitePlus
T343 O-Glycosylation GlyGen 25813380
T343 Phosphorylation PhosphoSitePlus
S369 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S369 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 20166139, 17525332, 26091039, ...18077418
T372 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T372 Phosphorylation HPRD   PhosphoSitePlus 20166139
S378 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T426 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S444 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 F4 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T64 M64 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S82 R82 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T160 M160 Biomuta DOID:1319 / brain cancer [ cosmic ]
S224 C224 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K229 R229 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T313 A313 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]