iPTMnet Report for Q02446 (SP4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q02446 / SP4_HUMAN
Protein Name Transcription factor Sp4
Gene Name Name: SP4
Organism Homo sapiens (Human)

PRO ID PR:Q02446
DAG View
PRO Name transcription factor Sp4 (human)
Definition A transcription factor Sp4 that is encoded in the genome of human.
Short Label hSP4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q02446 (SP4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T20 Phosphorylation PhosphoSitePlus
T37 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus   UniProt 23186163
S124 Phosphorylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
S130 O-Glycosylation GlyGen 26431879, 34019948, 29351928
S130 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
S136 Phosphorylation HPRD   PhosphoSitePlus 19413330, 19664995
T138 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 15302935
S160 O-Glycosylation GlyGen 26431879, 34019948, 29351928
T173 O-Glycosylation GlyGen 26431879, 34019948, 29351928
T184 O-Glycosylation GlyGen 26431879, 34019948, 29351928
S186 O-Glycosylation GlyGen 26431879, 34019948, 29351928
S187 O-Glycosylation GlyGen 26431879, 34019948, 29351928
S188 O-Glycosylation GlyGen 26431879, 34019948, 29351928
R457 Methylation PhosphoSitePlus
T495 O-Glycosylation GlyGen 26431879, 34019948, 29351928
T497 O-Glycosylation GlyGen 26431879, 34019948, 29351928
S500 O-Glycosylation GlyGen 26431879, 34019948, 29351928
S501 O-Glycosylation GlyGen 26431879, 34019948, 29351928
S502 O-Glycosylation GlyGen 26431879, 34019948, 29351928
T505 O-Glycosylation GlyGen 26431879, 34019948, 29351928
T506 O-Glycosylation GlyGen 26431879, 34019948, 29351928
S529 O-Glycosylation GlyGen 26431879, 34019948, 29351928
T535 O-Glycosylation GlyGen 26431879, 34019948, 29351928
S537 O-Glycosylation GlyGen 26431879, 34019948, 29351928
T574 O-Glycosylation GlyGen 26431879, 34019948, 29351928
T579 O-Glycosylation GlyGen 26431879, 34019948, 29351928
T589 O-Glycosylation GlyGen 26431879, 34019948, 29351928
T589 Phosphorylation PhosphoSitePlus
T599 O-Glycosylation GlyGen 26431879, 34019948, 29351928
S610 O-Glycosylation GlyGen 26431879, 34019948, 29351928
K643 Sumoylation PhosphoSitePlus
T672 Phosphorylation PhosphoSitePlus
S691 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T700 Phosphorylation PhosphoSitePlus
T702 Phosphorylation PhosphoSitePlus
S757 Phosphorylation PhosphoSitePlus
S767 Phosphorylation HPRD   PhosphoSitePlus 20068231
S770 Phosphorylation PhosphoSitePlus   RLIMS-P 25915526, 24475768, 26049820
T774 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T20 A20 Biomuta DOID:3571 / liver cancer [ cosmic ]
S124 L124 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
S187 L187 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S501 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S502 T502 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S537 T537 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T589 M589 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T589 S589 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T700 A700 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S767 Y767 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S767 T767 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S770 L770 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]