iPTMnet Report for Q02127 (DHODH)
Protein Information
UniProt AC / UniProt ID | Q02127 / PYRD_HUMAN |
Protein Name | Dihydroorotate dehydrogenase (quinone), mitochondrial precursor |
Gene Name | Name: DHODH |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q02127 |
PRO Name | dihydroorotate dehydrogenase (quinone), mitochondrial (human) |
Definition | A dihydroorotate dehydrogenase (quinone), mitochondrial that is encoded in the genome of human. |
Short Label | hDHODH |
Category | organism-gene |
Q02127 (DHODH) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T62 | Phosphorylation | score1 | PhosphoSitePlus | |||
S63 | Phosphorylation | score1 | PhosphoSitePlus | |||
K86 | Ubiquitination | score1 | PhosphoSitePlus | |||
K99 | Ubiquitination | score1 | PhosphoSitePlus | |||
T121 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20058876 | ||
Y146 | Phosphorylation | score1 | PhosphoSitePlus | |||
K169 | Ubiquitination | score1 | PhosphoSitePlus | |||
K183 | Ubiquitination | score1 | PhosphoSitePlus | |||
K185 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y194 | Phosphorylation | score1 | PhosphoSitePlus | |||
S214 | Phosphorylation | score1 | PhosphoSitePlus | |||
T217 | Phosphorylation | score1 | PhosphoSitePlus | |||
K226 | Ubiquitination | score1 | PhosphoSitePlus | |||
K235 | Ubiquitination | score1 | PhosphoSitePlus | |||
K254 | Ubiquitination | score1 | PhosphoSitePlus | |||
K264 | Ubiquitination | score1 | PhosphoSitePlus | |||
K306 | Ubiquitination | score1 | PhosphoSitePlus | |||
K344 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y355 | Phosphorylation | score1 | PhosphoSitePlus | |||
T356 | Phosphorylation | score1 | PhosphoSitePlus | |||
T359 | Phosphorylation | score1 | PhosphoSitePlus | |||
K378 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
T62 | N62 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
K344 | R344 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
T356 | M356 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] | |
T359 | S359 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
T359 | I359 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] |