iPTMnet Report for Q02078 (MEF2A)
Protein Information
UniProt AC / UniProt ID | Q02078 / MEF2A_HUMAN |
Protein Name | Myocyte-specific enhancer factor 2A |
Gene Name | Name: MEF2A Synonyms:MEF2; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q02078 |
PRO Name | myocyte-specific enhancer factor 2A (human) |
Definition | A myocyte-specific enhancer factor 2A that is encoded in the genome of human. |
Short Label | hMEF2A |
Category | organism-gene |
Q02078 (MEF2A) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T20 | Phosphorylation | score0 | RLIMS-P | 15735306 | ||
K23 | Ubiquitination | score1 | PhosphoSitePlus | |||
K30 | Phosphorylation | score1 | UniProt | 18669648 | ||
S59 | Phosphorylation | score1 | PhosphoSitePlus | |||
K64 | Ubiquitination | score1 | PhosphoSitePlus | |||
K68 | Ubiquitination | score1 | PhosphoSitePlus | |||
S98 | Phosphorylation | Q16539 (MAPK14) | score4 | phospho.ELM PhosphoSitePlus UniProt | 12586839, 18669648, 23186163 | |
T103 | Phosphorylation | score1 | PhosphoSitePlus | |||
S104 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y105 | Phosphorylation | score1 | PhosphoSitePlus | |||
T108 | Phosphorylation | Q16539 (MAPK14) | score4 | phospho.ELM PhosphoSitePlus | 12586839, 18669648 | |
T111 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y115 | Phosphorylation | score1 | PhosphoSitePlus | |||
S192 | Phosphorylation | Q16539 (MAPK14) | score2 | PhosphoSitePlus | 12586839 | |
S223 | Phosphorylation | Q16539 (MAPK14) | score2 | PhosphoSitePlus | 12586839 | |
S235 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
S246 | Phosphorylation | score1 | PhosphoSitePlus | |||
K249 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
T253 | Phosphorylation | score1 | PhosphoSitePlus | |||
S255 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus UniProt | 12586839, 18669648, 23186163 | ||
S280 | O-Glycosylation | score1 | GlyGen | 34846842, 33214551, 31492838, ... | ||
S281 | O-Glycosylation | score1 | GlyGen | 33214551, 32938750, 31492838, ... | ||
S289 | Phosphorylation | P68400 (CSNK2A1) | score3 | phospho.ELM PhosphoSitePlus | 12586839 | |
T312 | Phosphorylation | Q16539 (MAPK14) , Q13164 (MAPK7) | score4 | neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt | 9858528, 10849446, 10330143, ... | |
T319 | Phosphorylation | Q13164 (MAPK7) , Q16539 (MAPK14) | score4 | neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt | 12586839, 10849446, 10330143, ... | |
S355 | Phosphorylation | Q16539 (MAPK14) , Q13164 (MAPK7) | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor UniProt | 10849446, 9858528 | |
K403 | Acetylation | score1 | PhosphoSitePlus | |||
K403 | Sumoylation | score1 | PhosphoSitePlus | |||
S408 | Phosphorylation | Q00535 (CDK5) , Q16539 (MAPK14) | score4 | neXtProt phospho.ELM PRO PhosphoSitePlus Signor UniProt | 12586839, 12691662, 16484498, ... | |
S453 | Phosphorylation | Q16539 (MAPK14) | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor UniProt | 12586839, 9858528 | |
S457 | Phosphorylation | score1 | PhosphoSitePlus | |||
S479 | Phosphorylation | Q16539 (MAPK14) | score4 | neXtProt PhosphoSitePlus | 12586839, 9858528 | |
S494 | Phosphorylation | Q16539 (MAPK14) | score2 | PhosphoSitePlus | 12586839 | |
S496 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T312 | Phosphorylation | PR:Q13164 (hMAPK7) | score2 | PRO | 10849446 | |
T319 | Phosphorylation | PR:Q13164 (hMAPK7) | score2 | PRO | 10849446 | |
S355 | Phosphorylation | score2 | PRO | 10849446 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S82 | Phosphorylation | score1 | PhosphoSitePlus | |||
T87 | Phosphorylation | score1 | PhosphoSitePlus | |||
S98 | Phosphorylation | score1 | PhosphoSitePlus | |||
S108 | Phosphorylation | score1 | PhosphoSitePlus | |||
S111 | Phosphorylation | score1 | PhosphoSitePlus | |||
K117 | Ubiquitination | score1 | PhosphoSitePlus | |||
K127 | Ubiquitination | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S98 | Phosphorylation | score0 | HPRD | 18669648 | ||
T108 | Phosphorylation | score0 | HPRD | 18669648 | ||
S235 | Phosphorylation | score0 | HPRD | 18669648, 18212344, 20068231 | ||
S255 | Phosphorylation | score0 | HPRD | 18669648 | ||
T304 | Phosphorylation | Q16539 (MAPK14) , Q13164 (MAPK7) | score2 | HPRD | 10849446, 9858528 | |
T311 | Phosphorylation | Q13164 (MAPK7) , Q16539 (MAPK14) | score2 | HPRD | 10849446, 9858528 | |
S347 | Phosphorylation | Q13164 (MAPK7) | score1 | HPRD | 10849446 | |
S400 | Phosphorylation | Q00535 (CDK5) | score1 | HPRD | 12691662 | |
S445 | Phosphorylation | Q16539 (MAPK14) | score1 | HPRD | 9858528 | |
S488 | Phosphorylation | score0 | HPRD | 20068231 |
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000048365 (hMEF2A/Phos:2) | pS408 | PRO | |||
PR:000048366 (hMEF2A/Phos:3) | pT312,pT319 | PRO | |||
PR:000029010 (hMEF2A/iso:1/Phos:1) | pS355 | PRO | 10849446 | ||
PR:000029010 (hMEF2A/iso:1/Phos:1) | pT312,pT319 | PR:Q13164 (hMAPK7) | PRO | 10849446 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S82 | L82 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] | |
S111 | L111 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
S235 | F235 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] | |
S255 | F255 | Biomuta | DOID:4362 / cervical cancer [ cosmic ] | |
S347 | L347 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
S347 | * | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
S445 | Y445 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] |