iPTMnet Report for Q01959 (SLC6A3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q01959 / SC6A3_HUMAN
Protein Name Sodium-dependent dopamine transporter
Gene Name Name: SLC6A3
Synonyms:DAT1;
Organism Homo sapiens (Human)

PRO ID PR:Q01959
DAG View
PRO Name sodium-dependent dopamine transporter (human)
Definition A sodium-dependent dopamine transporter that is encoded in the genome of human.
Short Label hSLC6A3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q01959 (SLC6A3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus   RLIMS-P 24880859
S4 Phosphorylation PhosphoSitePlus   RLIMS-P 24880859
K5 Ubiquitination PhosphoSitePlus
S7 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 23161550, 28571709, 15024426
S7 Phosphorylation P17612 (PRKACA) neXtProt 23161550
S12 Phosphorylation PhosphoSitePlus   RLIMS-P 28571709
S13 Phosphorylation PhosphoSitePlus
T48 Phosphorylation PhosphoSitePlus
S53 Phosphorylation neXtProt   PhosphoSitePlus 19146407
S53 Phosphorylation P28482 (MAPK1) neXtProt 19146407
T62 Phosphorylation PhosphoSitePlus
T278 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
Y593 Phosphorylation PhosphoSitePlus
T613 Phosphorylation PhosphoSitePlus   RLIMS-P 22514303


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q16623 (STX1A) S14 Q01959 (SLC6A3) unknown eFIP 25774383


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 I4 Biomuta DOID:363 / uterine cancer [ icgc ]
S4 R4 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S7 A7 Biomuta DOID:1319 / brain cancer [ cosmic ]
S12 F12 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S13 P13 Biomuta DOID:3571 / liver cancer [ cosmic ]
T613 K613 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T613 M613 Biomuta DOID:10534 / stomach cancer [ cosmic ]