iPTMnet Report for Q01813 (PFKP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q01813 / PFKAP_HUMAN
Protein Name ATP-dependent 6-phosphofructokinase, platelet type
Gene Name Name: PFKP
Synonyms:PFKF;
Organism Homo sapiens (Human)

PRO ID PR:Q01813
DAG View
PRO Name ATP-dependent 6-phosphofructokinase, platelet type (human)
Definition An ATP-dependent 6-phosphofructokinase, platelet type that is encoded in the genome of human.
Short Label hPFKP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q01813 (PFKP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
S6 Phosphorylation PhosphoSitePlus   UniProt 23186163
K10 Ubiquitination PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus   UniProt 23186163
K25 Ubiquitination PhosphoSitePlus
Y52 Phosphorylation PhosphoSitePlus
Y64 Phosphorylation PhosphoSitePlus   RLIMS-P 29677490, 32195176, 35917090
K109 Acetylation PhosphoSitePlus
K109 Methylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
C112 Methylation IEDB 31844290
K139 Ubiquitination PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
K156 Acetylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
T211 Phosphorylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
R310 Methylation PhosphoSitePlus
T313 Phosphorylation PhosphoSitePlus
R319 Methylation PhosphoSitePlus
S386 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 21406692, 23186163, ...17081983, 29038421, 33607258, 33588886, 18669648, 20068231, 16964243
T393 Phosphorylation PhosphoSitePlus
K395 Acetylation PhosphoSitePlus   UniProt 19608861
K395 Ubiquitination PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
C411 S-Nitrosylation dbSNO 22126794
Y447 Phosphorylation PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
K480 Acetylation PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
K486 Acetylation PhosphoSitePlus   UniProt 19608861
K486 Ubiquitination PhosphoSitePlus
Y487 Phosphorylation PhosphoSitePlus
T538 O-Glycosylation GlyGen 33214551, 34725712, 26853435, ...22923583, 29351928, 34019948
S546 O-Glycosylation GlyGen 29351928
K567 Ubiquitination PhosphoSitePlus
K574 Acetylation PhosphoSitePlus
Y586 Phosphorylation PhosphoSitePlus
K625 Ubiquitination PhosphoSitePlus
K627 Ubiquitination PhosphoSitePlus
Y645 Phosphorylation PhosphoSitePlus
Y651 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455
Y654 Phosphorylation PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
K688 Acetylation PhosphoSitePlus   UniProt 19608861
K688 Ubiquitination PhosphoSitePlus
K700 Acetylation PhosphoSitePlus
K710 Acetylation PhosphoSitePlus
C718 Methylation IEDB 31844290
K724 Ubiquitination PhosphoSitePlus
K736 Acetylation PhosphoSitePlus
K736 Methylation PhosphoSitePlus
K736 Ubiquitination PhosphoSitePlus
K737 Methylation PhosphoSitePlus
K737 Ubiquitination PhosphoSitePlus
K747 Acetylation PhosphoSitePlus
K747 Ubiquitination PhosphoSitePlus
K753 Ubiquitination PhosphoSitePlus
K759 Ubiquitination PhosphoSitePlus
K765 Ubiquitination PhosphoSitePlus
S783 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 15302935, 18669648, ...19690332, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S142 Phosphorylation HPRD 20068231
S386 Phosphorylation HPRD 18691976, 16964243, 20058876, ...19664994, 19664995, 19651622, 17322306, 18669648, 18767875, 20068231
T393 Phosphorylation HPRD 17081983
Y645 Phosphorylation HPRD 17016520
Y651 Phosphorylation HPRD 15592455
S783 Phosphorylation HPRD 18691976, 18669648, 15302935, ...20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S21 C21 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K156 N156 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S386 R386 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K400 T400 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C411 Y411 Biomuta DOID:3571 / liver cancer [ cosmic ]
K459 I459 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K627 N627 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K700 N700 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]