iPTMnet Report for Q01196 (RUNX1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q01196 / RUNX1_HUMAN
Protein Name Runt-related transcription factor 1
Gene Name Name: RUNX1
Synonyms:AML1,CBFA2;
Organism Homo sapiens (Human)

PRO ID PR:Q01196
DAG View
PRO Name runt-related transcription factor 1 (human)
Definition A runt-related transcription factor 1 that is encoded in the genome of human.
Short Label hRUNX1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q01196 (RUNX1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T14 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 15302935, 35959452, ...18669648, 32387766, 19690332
S17 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T18 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 35959452, 18669648
S21 Phosphorylation Q00534 (CDK6) , P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 15302935, 18669648, 23186163, ...21059642
K24 Acetylation PhosphoSitePlus   UniProt 19608861
K24 Ubiquitination PhosphoSitePlus
K43 Acetylation PhosphoSitePlus   UniProt 19608861
K43 Ubiquitination PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
S145 O-Glycosylation GlyGen 27655845, 33214551, 34019948, ...29351928, 35132862, 35254053
K167 Ubiquitination PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
K188 Acetylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus   UniProt 23186163
S199 Phosphorylation PhosphoSitePlus
R206 Methylation PhosphoSitePlus
T207 Phosphorylation PhosphoSitePlus   RLIMS-P 32549768
R210 Methylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T219 Phosphorylation PhosphoSitePlus
R223 Methylation PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
S229 Phosphorylation phospho.ELM 18669648
T230 O-Glycosylation GlyGen 27655845, 33214551, 34019948, ...29351928, 35132862, 35254053
T230 Phosphorylation phospho.ELM 18669648
S238 O-Glycosylation GlyGen 27655845, 33214551, 34019948, ...29351928, 35132862, 35254053
S238 Phosphorylation PhosphoSitePlus
S249 Phosphorylation P28482 (MAPK1) , Q00534 (CDK6) , Q9H2X6 (HIPK2) , P24941 (CDK2) , P06493 (CDK1) IEDB   neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 30349386, 18695000, 32157095, ...16046550, 16917507, 8668214, 32387766, 19690332
S253 Phosphorylation PhosphoSitePlus
Y254 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
Y258 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
S266 Phosphorylation P28482 (MAPK1) , P24941 (CDK2) , Q00534 (CDK6) , P06493 (CDK1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16046550, 8668214, 30349386, ...19690332
S268 Phosphorylation PhosphoSitePlus   UniProt 19690332
T273 Phosphorylation P24941 (CDK2) , Q9H2X6 (HIPK2) , P06493 (CDK1) , P28482 (MAPK1) , Q00534 (CDK6) PhosphoSitePlus   Signor   UniProt 16046550, 18695000
S276 Phosphorylation P24941 (CDK2) , P06493 (CDK1) , P28482 (MAPK1) , Q00534 (CDK6) , Q9H2X6 (HIPK2) neXtProt   PhosphoSitePlus   Signor   UniProt 18695000, 19690332, 17015473, ...16046550, 16917507, 21059642
S292 Phosphorylation PhosphoSitePlus
S295 O-Glycosylation GlyGen 27655845, 33214551, 34019948, ...29351928, 35132862, 35254053
S295 Phosphorylation PhosphoSitePlus
T296 O-Glycosylation GlyGen 27655845, 33214551, 34019948, ...29351928, 35132862, 35254053
T296 Phosphorylation PhosphoSitePlus   UniProt 23186163
T301 O-Glycosylation GlyGen 27655845, 33214551, 34019948, ...29351928, 35132862, 35254053
R319 Methylation PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus
T331 Phosphorylation PhosphoSitePlus
S361 O-Glycosylation GlyGen 27655845, 33214551, 34019948, ...29351928, 35132862, 35254053
S362 O-Glycosylation GlyGen 27655845, 33214551, 34019948, ...29351928, 35132862, 35254053
S397 Phosphorylation P06493 (CDK1) , Q00534 (CDK6) PhosphoSitePlus   Signor 21059642
T406 O-Glycosylation GlyGen 32938750
S423 Phosphorylation PhosphoSitePlus
S433 Phosphorylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y453 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T14 Phosphorylation HPRD 19651622, 18669648, 15302935, ...20068231
S17 Phosphorylation HPRD 19651622, 18669648, 20068231
T18 Phosphorylation HPRD 19651622, 18669648
S21 Phosphorylation HPRD 19651622, 18669648, 15302935, ...20068231
K24 Acetylation PR:000007102 (EP300) PRO 14752096
K43 Acetylation PR:000007102 (EP300) PRO 14752096
S229 Phosphorylation HPRD 18669648
T230 Phosphorylation HPRD 18669648
S249 Phosphorylation Q9H2X6 (HIPK2) HPRD 169175071
S276 Phosphorylation Q9H2X6 (HIPK2) HPRD 16917507
T284 Phosphorylation HPRD 20068231
T285 Phosphorylation HPRD 20068231
S291 Phosphorylation HPRD 20068231
S292 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T458 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T41 Phosphorylation HPRD 19651622, 18669648, 15302935, ...20068231
S44 Phosphorylation HPRD 19651622, 18669648, 20068231
T45 Phosphorylation HPRD 19651622, 18669648
S48 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18669648, 15302935, ...20068231
R233 Methylation PhosphoSitePlus
R237 Methylation PhosphoSitePlus
S256 Phosphorylation HPRD 18669648
T257 Phosphorylation HPRD 18669648
S276 Phosphorylation Q00534 (CDK6) , P06493 (CDK1) , P24941 (CDK2) , P28482 (MAPK1) , P27361 (MAPK3) neXtProt   PhosphoSitePlus 17015473, 15475366
S293 Phosphorylation P06493 (CDK1) , Q00534 (CDK6) , P28482 (MAPK1) , P24941 (CDK2) , P27361 (MAPK3) neXtProt   PhosphoSitePlus 17015473, 15475366
T300 Phosphorylation P28482 (MAPK1) , P24941 (CDK2) , Q00534 (CDK6) , P06493 (CDK1) , P27361 (MAPK3) neXtProt   PhosphoSitePlus 17015473, 15475366
S303 Phosphorylation P06493 (CDK1) , Q00534 (CDK6) , P24941 (CDK2) , P28482 (MAPK1) , P27361 (MAPK3) neXtProt   PhosphoSitePlus 17015473, 17023045, 15475366
T311 Phosphorylation HPRD 20068231
T312 Phosphorylation HPRD 20068231
S318 Phosphorylation HPRD 20068231
S319 Phosphorylation HPRD 20068231
T323 Phosphorylation PhosphoSitePlus
S424 Phosphorylation P06493 (CDK1) PhosphoSitePlus 21059642
S462 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) PhosphoSitePlus 15475366


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000028561 (hRUNX1/Ac:1) acK24,acK43 PR:000007102 (EP300) PRO 14752096


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T14 M14 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K24 N24 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T41 M41 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S50 R50 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S50 G50 Biomuta DOID:1612 / breast cancer [ cosmic ]
S67 R67 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S67 I67 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K83 N83 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K83 E83 Biomuta DOID:2531 / hematologic cancer [ civic, cosmic ]
K83 Q83 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K83 R83 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K90 N90 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
K90 * Biomuta DOID:1612 / breast cancer [ cosmic ]
K125 E125 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K144 N144 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K167 N167 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ]
S191 T191 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S199 R199 Biomuta DOID:1324 / lung cancer [ icgc ] DOID:2531 / hematologic cancer [ cosmic ]
S199 N199 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R206 H206 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R210 K210 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T219 M219 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
R223 H223 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R223 C223 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R223 P223 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S225 F225 Biomuta DOID:4159 / skin cancer [ cosmic ]
S229 P229 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S229 F229 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T230 S230 Biomuta DOID:1324 / lung cancer [ cosmic ]
R233 H233 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R237 K237 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y254 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S256 P256 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S256 F256 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T257 S257 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y258 C258 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S263 F263 Biomuta [ cosmic ]
S268 F268 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T273 M273 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ]
S276 L276 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S276 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S291 A291 Biomuta DOID:184 / bone cancer [ cosmic ]
S295 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T296 M296 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T300 M300 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ]
T301 I301 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S303 L303 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S303 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S318 A318 Biomuta DOID:184 / bone cancer [ cosmic ]
R319 H319 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R319 S319 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T323 M323 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S329 F329 Biomuta DOID:4159 / skin cancer [ cosmic ]
S361 L361 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S397 A397 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S397 L397 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S397 P397 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S424 P424 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S424 L424 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S424 A424 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S433 N433 Biomuta DOID:4159 / skin cancer [ cosmic ]
S435 F435 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y453 F453 Biomuta DOID:4159 / skin cancer [ cosmic ]
S462 F462 Biomuta DOID:4159 / skin cancer [ cosmic ]