iPTMnet Report for Q01167 (FOXK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q01167 / FOXK2_HUMAN
Protein Name Forkhead box protein K2
Gene Name Name: FOXK2
Synonyms:ILF;
Organism Homo sapiens (Human)

PRO ID PR:Q01167
DAG View
PRO Name forkhead box protein K2 (human)
Definition A forkhead box protein K2 that is encoded in the genome of human.
Short Label hFOXK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q01167 (FOXK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 20068231
S9 Phosphorylation PhosphoSitePlus
T13 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus   UniProt 20068231
S61 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K118 Ubiquitination PhosphoSitePlus
R130 Methylation PhosphoSitePlus
R144 Methylation PhosphoSitePlus   UniProt 24129315
T155 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 30379171, 30059200, 29351928, 35132862, 31492838, 32119511, 35289036, 35254053
S158 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 30379171, 30059200, 29351928, 35132862, 31492838, 32119511, 35289036, 35254053
S159 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 30379171, 30059200, 29351928, 35132862, 31492838, 32119511, 35289036, 35254053
K161 Sumoylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K164 Sumoylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
T203 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
Y222 Phosphorylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
S239 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163
S248 Phosphorylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
Y295 Phosphorylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
R314 Methylation PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
K328 Acetylation PhosphoSitePlus
K328 Sumoylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
T360 Phosphorylation PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
S373 Phosphorylation P24941 (CDK2) , P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18669648, 20810654
S381 Phosphorylation PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
T389 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 20810654
S392 Phosphorylation PhosphoSitePlus
S394 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S398 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 16964243, ...18669648, 20068231, 24275569, 19690332, 20810654
S424 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 35254053, 30379171, 29351928, 32938750, 34019948, 30059200, 35132862, 31492838, 32119511, 35289036, 30620550
S424 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S428 Phosphorylation P24941 (CDK2) , P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 23186163, 18220336, 18669648, ...20810654, 19690332, 20068231
S431 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
T438 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34019948, 30379171, 30059200, 29351928, 35132862, 31492838, 32119511, 35289036, 35254053
K527 Sumoylation PhosphoSitePlus
T548 O-Glycosylation GlyGen 32938750
T551 Phosphorylation PhosphoSitePlus
T552 Phosphorylation PhosphoSitePlus
T558 O-Glycosylation GlyGen 31373491
T558 Phosphorylation PhosphoSitePlus
S584 Phosphorylation PhosphoSitePlus
T587 Phosphorylation PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
K633 Sumoylation PhosphoSitePlus
T634 Phosphorylation PhosphoSitePlus
T648 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T13 Phosphorylation HPRD 19413330
S30 Phosphorylation HPRD 19413330, 20068231
S61 Phosphorylation HPRD 17525332
S170 Phosphorylation HPRD 20068231
S180 Phosphorylation HPRD 20068231
T183 Phosphorylation HPRD 20068231
T201 Phosphorylation HPRD 20068231
S205 Phosphorylation HPRD 20068231
S209 Phosphorylation HPRD 20068231
Y222 Phosphorylation HPRD 18452278
S239 Phosphorylation HPRD 17525332, 20068231, 18452278
S373 Phosphorylation HPRD 18669648, 18452278
T389 Phosphorylation HPRD 18669648
S394 Phosphorylation HPRD 18669648
S398 Phosphorylation HPRD 19413330, 17322306, 18767875, ...19664994, 19664995, 18452278, 19651622, 18669648, 20068231
S424 Phosphorylation HPRD 20068231
S428 Phosphorylation HPRD 19413330, 18669648, 20058876, ...19664995, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S170 Y170 Biomuta DOID:363 / uterine cancer [ icgc ]
S195 N195 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S199 F199 Biomuta DOID:1324 / lung cancer [ cosmic ]
T201 M201 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S248 L248 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
Y295 H295 Biomuta DOID:1324 / lung cancer [ cosmic ]
R314 C314 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S330 L330 Biomuta DOID:4159 / skin cancer [ cosmic ]
T360 I360 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S398 L398 Biomuta DOID:4159 / skin cancer [ cosmic ]
S428 L428 Biomuta DOID:4159 / skin cancer [ cosmic ]
T438 I438 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T548 M548 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T551 S551 Biomuta DOID:184 / bone cancer [ cosmic ]
S584 P584 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T587 S587 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K633 N633 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T648 M648 Biomuta DOID:9256 / colorectal cancer [ cosmic ]