iPTMnet Report for Q00613 (HSF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q00613 / HSF1_HUMAN
Protein Name Heat shock factor protein 1
Gene Name Name: HSF1
Synonyms:HSTF1;
Organism Homo sapiens (Human)

PRO ID PR:Q00613
DAG View
PRO Name heat shock factor protein 1 (human)
Definition A heat shock factor protein 1 that is encoded in the genome of human.
Short Label hHSF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q00613 (HSF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
S13 Phosphorylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K80 Acetylation PhosphoSitePlus   UniProt 24581496, 19229036
K91 Acetylation UniProt 24581496
K91 Ubiquitination PhosphoSitePlus
C103 Methylation IEDB 31844290
K116 Ubiquitination PhosphoSitePlus
K118 Acetylation PhosphoSitePlus   UniProt 26754925, 24581496
K118 Ubiquitination PhosphoSitePlus
T120 Phosphorylation PhosphoSitePlus   RLIMS-P 31409638
S121 Phosphorylation P49137 (MAPKAPK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19936221, 16278218, 25425574, ...15760475, 26754925
S123 O-Glycosylation GlyGen 30379171
T124 O-Glycosylation GlyGen 30379171
K126 Sumoylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
T142 Phosphorylation P19784 (CSNK2A2) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24312621, 15302935, 12659875, ...35080342
K150 Acetylation UniProt 24581496
K157 Sumoylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
K188 Acetylation UniProt 24581496
K208 Acetylation PhosphoSitePlus   UniProt 24581496
K208 Sumoylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
S216 Phosphorylation P53350 (PLK1) PhosphoSitePlus   RLIMS-P   Signor   UniProt 18794143, 19934326, 32457290
S218 Phosphorylation PhosphoSitePlus
K224 Sumoylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
S230 Phosphorylation Q9UQM7 (CAMK2A) , P53355 (DAPK1) , Q13557 (CAMK2D) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19945465, 11447121, 19910575, ...15302935, 25380824, 15760475, 28415561, 26018731, 26754925, 32457290
S275 Phosphorylation PhosphoSitePlus   UniProt 8940068
S279 Phosphorylation PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
S292 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 15760475
K298 Acetylation PhosphoSitePlus   UniProt 24581496
K298 Sumoylation PhosphoSitePlus
S303 Phosphorylation P49841 (GSK3B) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19945465, 11447121, 24589236, ...26785146, 28415561, 26754925, 27354066, 23186163, 28383811, 32457290, 9121459, 33493517, 12665592, 16371476, 24954509, 8940068, 31054961, 24275569, 20926391, 34239690, 12917326, 17081983, 24412756, 22768106, 15302935, 9660838, 18669648, 15760475, 8946918, 11162511
S307 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19945465, 11447121, 26785146, ...12646186, 28415561, 26754925, 27354066, 23186163, 28383811, 9121459, 33493517, 8940068, 31054961, 15760475, 34239690, 12917326, 17081983, 8946918, 15302935, 9660838, 18669648, 32457290, 9535852, 11162511
S314 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17081983, 18220336, 15760475, ...26754925, 19690332, 20068231
S319 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 15760475, 18220336
S320 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22216146, 21085490, 22768106, ...27189267, 26754925, 28415561
T323 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19690332, 17081983, 26754925, ...18220336
S326 Phosphorylation Q02750 (MAP2K1) , P42345 (MTOR) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 24516381, 29316077, 32302062, ...25199534, 24589236, 28415561, 31614463, 24763051, 28618124, 25728673, 26754925, 25811962, 22496356, 29606348, 27354066, 29296831, 27997575, 25406061, 18220336, 24126052, 24136149, 27639166, 20068231, 28542269, 24954509, 35080342, 19690332, 30138434, 32959058, 29059166, 29247221, 26010766, 31109102, 25679764, 24469056, 32448393, 27105490, 30038221, 26018731, 21085490, 22768106, 27791982, 29799521, 33407730, 27043084, 15760475, 29088759, 28381880, 35959699, 32457290
S333 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
S344 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 15760475
T355 Phosphorylation PhosphoSitePlus
T357 Phosphorylation PhosphoSitePlus
S363 Phosphorylation P45983 (MAPK8) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 17081983, 10747973, ...9660838, 18669648, 15760475, 24275569, 34239690, 29348836
T367 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 26754925
S368 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T369 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S375 Phosphorylation PhosphoSitePlus
C378 Methylation IEDB 31844290
S419 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 15661742, 15760475, 32457290
S444 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 15760475
S457 Phosphorylation PhosphoSitePlus
S501 Phosphorylation PhosphoSitePlus
K524 Acetylation PhosphoSitePlus   UniProt 24581496
T527 Phosphorylation PhosphoSitePlus   RLIMS-P 35080342
Site PTM Type PTM Enzyme Score Source PMID
S121 Phosphorylation HPRD   PRO 16278218
S127 Phosphorylation HPRD 20068231
T142 Phosphorylation P68400 (CSNK2A1) HPRD 12659875
S230 Phosphorylation Q9UQM7 (CAMK2A) HPRD 11447121
S292 Phosphorylation HPRD 19664994
S303 Phosphorylation P49840 (GSK3A) , PR:000008288 (GSK3B) HPRD   PRO 19413330, 12917326, 18212344, ...19664994, 9121459, 19651622, 18669648, 12665592, 20166139, 20068231
S307 Phosphorylation PR:000000104 (MAPK3) , P27361 (MAPK3) HPRD   PRO 19413330, 12917326, 18212344, ...19664994, 9121459, 19651622, 18669648, 20068231, 20166139, 8940068
S314 Phosphorylation HPRD 19651622, 20068231, 18452278
S319 Phosphorylation HPRD 19651622, 20068231, 18452278
S320 Phosphorylation HPRD 20068231, 18452278
T323 Phosphorylation HPRD 19664994, 20068231
S326 Phosphorylation HPRD 19651622, 15016915, 20068231
S363 Phosphorylation P45983 (MAPK8) HPRD 18767875, 10747973, 19651622, ...18669648, 20166139, 20068231
T367 Phosphorylation HPRD 19651622, 18669648, 20068231
S368 Phosphorylation HPRD 19651622, 18669648, 20068231
T369 Phosphorylation HPRD 17322306, 20166139, 18669648, ...20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047906 (hHSF1/Phos:3) pS303 PRO
PR:000047907 (hHSF1/Phos:2) pS303,pS307 PRO
PR:000047908 (hHSF1/Phos:4) pS307 PRO
PR:000025723 (hHSF1/iso:Long/Phos:1) pS121 PRO 16278218
PR:000025725 (hHSF1/iso:Long/Phos:2) pS307 PR:000000104 (MAPK3) PRO 12917326, 9121459
PR:000025725 (hHSF1/iso:Long/Phos:2) pS303 PR:000008288 (GSK3B) PRO 12917326, 9121459


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q00613 (HSF1) S303 P62258 (YWHAE) unknown eFIP 12917326
Phosphorylation Q00613 (HSF1) S121 P07900 (HSP90AA1) increased_association eFIP 16278218


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025723 (hHSF1/iso:Long/Phos:1) Interaction PR:P07900 (hHSP90AA1) PRO 16278218
PR:000025723 (hHSF1/iso:Long/Phos:1) Interaction PR:P08238 (hHSP90AB1) PRO 16278218
PR:000025725 (hHSF1/iso:Long/Phos:2) Interaction PR:P62258 (hYWHAE) PRO 12917326


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T120 A120 Biomuta DOID:1319 / brain cancer [ cosmic ]
K184 T184 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K208 N208 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S279 F279 Biomuta DOID:4159 / skin cancer [ cosmic ]
S283 N283 Biomuta DOID:3571 / liver cancer [ cosmic ]
S303 G303 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S320 F320 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T323 I323 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S333 F333 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S344 C344 Biomuta DOID:1324 / lung cancer [ cosmic ]
S363 P363 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
S368 P368 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S419 N419 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S419 G419 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]