iPTMnet Report for Q00610 (CLTC)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q00610 / CLH1_HUMAN
Protein Name Clathrin heavy chain 1
Gene Name Name: CLTC
Synonyms:CLH17,CLTCL2,KIAA0034;
Organism Homo sapiens (Human)

PRO ID PR:Q00610
DAG View
PRO Name clathrin heavy chain 1 (human)
Definition A clathrin heavy chain 1 that is encoded in the genome of human.
Short Label hCLTC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q00610 (CLTC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895, 25944712
T31 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus   UniProt 23186163
S70 Phosphorylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
S97 O-Glycosylation GlyGen 23301498, 16408927, 30444036, ...18369606, 35138101, 27655845, 30397120, 30379171, 34725712, 26853435, 33214551, 34019948, 35083852, 32119511, 36240223, 33465208
T105 Phosphorylation PhosphoSitePlus
R144 Methylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
C151 S-Nitrosylation dbSNO 19483679, 26338901
T158 Phosphorylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
K189 Acetylation PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
K205 Acetylation PhosphoSitePlus
K227 Acetylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
T235 Phosphorylation PhosphoSitePlus
T238 Phosphorylation PhosphoSitePlus
K245 Acetylation PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K367 Acetylation PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
Y377 Phosphorylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
T394 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 15302935, ...24275569
T397 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
T411 Phosphorylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
Y430 Phosphorylation PhosphoSitePlus
K450 Acetylation PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus
K456 Acetylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
T473 Phosphorylation PhosphoSitePlus
C491 Methylation IEDB 31844290
C491 S-Nitrosylation dbSNO 19483679
K500 Ubiquitination PhosphoSitePlus
K506 Acetylation PhosphoSitePlus
K507 Acetylation PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
Y510 Phosphorylation PhosphoSitePlus
Y556 Phosphorylation PhosphoSitePlus
K619 Methylation PhosphoSitePlus
K619 Ubiquitination PhosphoSitePlus
Y634 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 19690332
K637 Acetylation PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
C682 Methylation IEDB 31844290
C736 S-Nitrosylation dbSNO 19483679
K737 Ubiquitination PhosphoSitePlus
K742 Acetylation PhosphoSitePlus
K742 Ubiquitination PhosphoSitePlus
S751 Phosphorylation PhosphoSitePlus
K760 Ubiquitination PhosphoSitePlus
K764 Acetylation PhosphoSitePlus
K764 Ubiquitination PhosphoSitePlus
K798 Acetylation PhosphoSitePlus
K798 Ubiquitination PhosphoSitePlus
Y799 Phosphorylation PhosphoSitePlus
Y803 Phosphorylation PhosphoSitePlus
K806 Ubiquitination PhosphoSitePlus
S825 Phosphorylation PhosphoSitePlus
S841 Phosphorylation PhosphoSitePlus
T842 Phosphorylation PhosphoSitePlus
K851 Ubiquitination PhosphoSitePlus
K856 Acetylation PhosphoSitePlus   UniProt 19608861
K856 Ubiquitination PhosphoSitePlus
K881 Ubiquitination PhosphoSitePlus
Y883 Phosphorylation PhosphoSitePlus
Y899 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
Y900 Phosphorylation PhosphoSitePlus
S902 Phosphorylation PhosphoSitePlus
R903 Methylation PhosphoSitePlus
K907 Acetylation PhosphoSitePlus
K907 Ubiquitination PhosphoSitePlus
K911 Ubiquitination PhosphoSitePlus
C918 S-Nitrosylation dbSNO 19483679
C926 S-Nitrosylation dbSNO 19483679
C934 S-Nitrosylation dbSNO 19483679
S938 Phosphorylation PhosphoSitePlus
K941 Ubiquitination PhosphoSitePlus
S1016 Phosphorylation PhosphoSitePlus
S1019 Phosphorylation PhosphoSitePlus
K1034 Ubiquitination PhosphoSitePlus
K1074 Acetylation PhosphoSitePlus
K1074 Ubiquitination PhosphoSitePlus
Y1096 Phosphorylation PhosphoSitePlus
C1102 S-Nitrosylation dbSNO 2212679, 22126794
S1109 Phosphorylation PhosphoSitePlus
K1118 Ubiquitination PhosphoSitePlus
K1122 Ubiquitination PhosphoSitePlus
K1130 Ubiquitination PhosphoSitePlus
Y1137 Phosphorylation PhosphoSitePlus
K1155 Acetylation PhosphoSitePlus
S1167 Phosphorylation PhosphoSitePlus
K1179 Ubiquitination PhosphoSitePlus
T1180 O-Glycosylation GlyGen 23301498, 16408927, 30444036, ...18369606, 35138101, 27655845, 30397120, 30379171, 34725712, 26853435, 33214551, 34019948, 35083852, 32119511, 36240223, 33465208
T1180 Phosphorylation PhosphoSitePlus
Y1206 Phosphorylation PhosphoSitePlus
K1209 Acetylation PhosphoSitePlus
K1209 Ubiquitination PhosphoSitePlus
Y1211 Phosphorylation PhosphoSitePlus
K1215 Ubiquitination PhosphoSitePlus
Y1218 Phosphorylation PhosphoSitePlus
S1222 Phosphorylation PhosphoSitePlus
R1226 Methylation PhosphoSitePlus
S1229 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1230 Phosphorylation PhosphoSitePlus
Y1237 Phosphorylation PhosphoSitePlus
K1254 Ubiquitination PhosphoSitePlus
K1264 Acetylation PhosphoSitePlus
K1264 Ubiquitination PhosphoSitePlus
T1318 Phosphorylation PhosphoSitePlus
S1341 Phosphorylation PhosphoSitePlus
K1347 Ubiquitination PhosphoSitePlus
K1387 Ubiquitination PhosphoSitePlus
K1392 Ubiquitination PhosphoSitePlus
T1396 Phosphorylation PhosphoSitePlus
K1397 Ubiquitination PhosphoSitePlus
Y1404 Phosphorylation PhosphoSitePlus
Y1405 Phosphorylation PhosphoSitePlus
Y1438 Phosphorylation PhosphoSitePlus
S1440 Phosphorylation PhosphoSitePlus
K1441 Acetylation PhosphoSitePlus   UniProt 19608861
K1441 Methylation PhosphoSitePlus
K1441 Ubiquitination PhosphoSitePlus
K1443 Ubiquitination PhosphoSitePlus
K1449 Acetylation PhosphoSitePlus
K1449 Ubiquitination PhosphoSitePlus
K1461 Ubiquitination PhosphoSitePlus
S1462 Phosphorylation PhosphoSitePlus
S1466 Phosphorylation PhosphoSitePlus
Y1477 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   Signor   UniProt 10089883, 12237126, 19690332
T1482 Phosphorylation PhosphoSitePlus
Y1487 Phosphorylation PhosphoSitePlus
S1494 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 15302935, 24275569, ...23186163
K1501 Acetylation PhosphoSitePlus   UniProt 19608861
K1501 Ubiquitination PhosphoSitePlus
Y1513 Phosphorylation PhosphoSitePlus
K1516 Acetylation PhosphoSitePlus
K1522 Ubiquitination PhosphoSitePlus
S1524 Phosphorylation PhosphoSitePlus
K1529 Ubiquitination PhosphoSitePlus
K1535 Acetylation PhosphoSitePlus
K1535 Ubiquitination PhosphoSitePlus
S1544 Phosphorylation PhosphoSitePlus
T1608 Phosphorylation PhosphoSitePlus
K1609 Ubiquitination PhosphoSitePlus
K1612 Ubiquitination PhosphoSitePlus
S1618 Phosphorylation PhosphoSitePlus
K1621 Acetylation PhosphoSitePlus
Y1634 Phosphorylation PhosphoSitePlus
Y1657 Phosphorylation PhosphoSitePlus
Y1659 Phosphorylation PhosphoSitePlus
T1660 Phosphorylation PhosphoSitePlus
Y1664 Phosphorylation PhosphoSitePlus
Y1673 Phosphorylation PhosphoSitePlus
S1674 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T394 Phosphorylation HPRD 20166139, 18691976, 18669648, ...15302935, 18452278
T411 Phosphorylation HPRD 18691976
S412 Phosphorylation HPRD 20068231
Y634 Phosphorylation HPRD 18083107
S672 Phosphorylation HPRD 20068231
Y883 Phosphorylation HPRD 18691976
Y899 Phosphorylation HPRD 18083107
S1016 Phosphorylation HPRD 20068231
S1019 Phosphorylation HPRD 20068231
Y1477 Phosphorylation HPRD 12237126
S1494 Phosphorylation HPRD 15302935
S1616 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9Y6A5 (TACC3) S558 Q00610 (CLTC) unknown eFIP 23861900


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S97 R97 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S97 C97 Biomuta DOID:1324 / lung cancer [ cosmic ]
R144 C144 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T158 I158 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K227 N227 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T235 I235 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K456 E456 Biomuta DOID:4159 / skin cancer [ cosmic ]
K456 N456 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
C682 F682 Biomuta DOID:4159 / skin cancer [ cosmic ]
K737 N737 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K760 Q760 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K760 N760 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S841 Y841 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K851 T851 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y900 H900 Biomuta DOID:363 / uterine cancer [ icgc ]
R903 C903 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K911 R911 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S1462 Y1462 Biomuta DOID:363 / uterine cancer [ icgc ]
S1494 L1494 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S1524 T1524 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K1535 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S1544 C1544 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T1608 A1608 Biomuta DOID:363 / uterine cancer [ icgc ]
S1618 * Biomuta DOID:363 / uterine cancer [ cosmic ]
T1660 I1660 Biomuta DOID:363 / uterine cancer [ icgc ]
Y1664 C1664 Biomuta DOID:5041 / esophageal cancer [ cosmic ]