iPTMnet Report for Q00536 (CDK16)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q00536 / CDK16_HUMAN
Protein Name Cyclin-dependent kinase 16
Gene Name Name: CDK16
Synonyms:PCTAIRE1,PCTK1;
Organism Homo sapiens (Human)

PRO ID PR:Q00536
DAG View
PRO Name cyclin-dependent kinase 16 (human)
Definition A cyclin-dependent kinase 16 that is encoded in the genome of human.
Short Label hCDK16
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q00536 (CDK16) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation Q8IWQ3 (BRSK2) , P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 22798068, 23186163, 12154078
T14 Phosphorylation PhosphoSitePlus
R19 Methylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus   UniProt 19369195
S64 Phosphorylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 32098961, 23186163
S78 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
S82 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
S86 Phosphorylation PhosphoSitePlus
T88 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
S95 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19369195, 12084709, 23186163, ...18691976, 21335063
K108 Acetylation PhosphoSitePlus
S110 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus 12154078
T111 Phosphorylation PhosphoSitePlus
K116 Acetylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
S119 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 21406692, 19369195, ...17192257, 33889818, 12154078, 32098961
K133 Ubiquitination PhosphoSitePlus
T135 Phosphorylation PhosphoSitePlus
S138 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 19369195, ...18847512, 17192257, 18669648
K143 Ubiquitination PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
S153 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 23186163, 22184064, ...17192257, 18669648, 12154078, 20068231
S155 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 18669648, 32098961
T164 Phosphorylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
T175 Phosphorylation PhosphoSitePlus
Y176 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T178 Phosphorylation PhosphoSitePlus
Y180 Phosphorylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
C206 Methylation IEDB 31844290
K216 Ubiquitination PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
S319 Phosphorylation phospho.ELM 12154078
T380 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
S480 Phosphorylation phospho.ELM   PhosphoSitePlus 12154078
Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation P17612 (PRKACA) HPRD 18691976, 12154078
S36 Phosphorylation HPRD 18691976
S42 Phosphorylation HPRD 18691976
S64 Phosphorylation HPRD 18691976
S65 Phosphorylation HPRD 18691976
S78 Phosphorylation HPRD 18691976, 18452278
S82 Phosphorylation HPRD 18691976
S86 Phosphorylation HPRD 18691976
T88 Phosphorylation HPRD 18691976
S89 Phosphorylation HPRD 18691976
S90 Phosphorylation HPRD 18691976
S95 Phosphorylation Q00535 (CDK5) HPRD 18691976, 12084709
S110 Phosphorylation P17612 (PRKACA) HPRD 19651622, 18691976, 12154078, ...20068231
S119 Phosphorylation P17612 (PRKACA) HPRD 17322306, 18691976, 19651622, ...18212344, 20068231
T135 Phosphorylation HPRD 18691976
S138 Phosphorylation Q00536 (CDK16) HPRD 19413330, 18691976, 18669648, ...18212344, 17192257
S153 Phosphorylation P17612 (PRKACA) HPRD 18691976, 18212344, 18767875, ...19651622, 17322306, 18669648, 20068231
S155 Phosphorylation HPRD 18669648
T175 Phosphorylation HPRD 19651622, 20068231
Y176 Phosphorylation HPRD 19651622, 19901323, 20068231
T178 Phosphorylation HPRD 19651622, 20068231
Y180 Phosphorylation HPRD 20068231
S480 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
T30 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation P17612 (PRKACA) HPRD 18691976, 12154078
S42 Phosphorylation HPRD 18691976
S48 Phosphorylation HPRD 18691976
S70 Phosphorylation HPRD 18691976
S71 Phosphorylation HPRD 18691976
S84 Phosphorylation HPRD 18691976, 18452278
S88 Phosphorylation HPRD 18691976
S92 Phosphorylation HPRD 18691976
T94 Phosphorylation HPRD 18691976
S95 Phosphorylation HPRD 18691976
S96 Phosphorylation HPRD 18691976
S101 Phosphorylation Q00535 (CDK5) HPRD 18691976, 12084709
S116 Phosphorylation P17612 (PRKACA) HPRD 19651622, 18691976, 12154078, ...20068231
S125 Phosphorylation P17612 (PRKACA) HPRD 17322306, 18691976, 19651622, ...18212344, 20068231
T141 Phosphorylation HPRD 18691976
S144 Phosphorylation Q00536 (CDK16) HPRD 19413330, 18691976, 18669648, ...18212344, 17192257
S159 Phosphorylation P17612 (PRKACA) HPRD 18691976, 18212344, 18767875, ...19651622, 17322306, 18669648, 20068231
S161 Phosphorylation HPRD 18669648
T181 Phosphorylation HPRD 19651622, 20068231
Y182 Phosphorylation HPRD 19651622, 19901323, 20068231
T184 Phosphorylation HPRD 19651622, 20068231
Y186 Phosphorylation HPRD 20068231
S486 Phosphorylation HPRD 18691976


Q00536 (CDK16) as PTM Enzyme



Substrate Site Score Source PMID
O43663 (PRC1) T481 Signor 35449080
P10644 (PRKAR1A) S83 PhosphoSitePlus   Signor 25605337
P46527 (CDKN1B) S10 PhosphoSitePlus   Signor 25205104
Q00536-1 (CDK16) S138 HPRD 19413330, 18691976, 18669648, ...18212344, 17192257
Q00536-3 (CDK16) S144 HPRD 19413330, 18691976, 18669648, ...18212344, 17192257
Q8ND76 (CCNY) S336 PhosphoSitePlus 26205494


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q8ND76 (CCNY) S326 Q00536 (CDK16) unknown eFIP 32098961


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R19 Q19 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
R19 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S42 N42 Biomuta DOID:4159 / skin cancer [ cosmic ]
S48 N48 Biomuta DOID:4159 / skin cancer [ cosmic ]
S78 Y78 Biomuta DOID:363 / uterine cancer [ icgc ]
S84 Y84 Biomuta DOID:363 / uterine cancer [ icgc ]
S86 L86 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S92 L92 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K288 T288 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K301 T301 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S319 F319 Biomuta DOID:4159 / skin cancer [ cosmic ]
S479 L479 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]