Protein Information

Cytoscape View


UniProt AC / UniProt ID Q00403 / TF2B_HUMAN
Protein Name Transcription initiation factor IIB
Gene Name Name: GTF2B
Synonyms:TF2B,TFIIB;
Organism Homo sapiens (Human)

PRO ID PR:Q00403
DAG View
PRO Name transcription initiation factor IIB (human)
Definition A transcription initiation factor IIB that is encoded in the genome of human.
Short Label hGTF2B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q00403 (GTF2B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
S5 Phosphorylation RLIMS-P 20226668
Y27 Phosphorylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus   RLIMS-P 20226668, 23115335
S70 Phosphorylation PhosphoSitePlus   UniProt 23186163
S76 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
K86 Ubiquitination PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus   UniProt 23186163
K100 Ubiquitination PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
T123 Phosphorylation PhosphoSitePlus
R127 Methylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
C181 Methylation IEDB 31844290
C194 Methylation IEDB 31844290
K238 Acetylation Q00403 (GTF2B) PhosphoSitePlus   UniProt 12931194
K238 Ubiquitination PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
T270 Phosphorylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
T284 Phosphorylation PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus


Q00403 (GTF2B) as PTM Enzyme



Substrate Site Score Source PMID
Q00403 (GTF2B) K238 UniProt 12931194


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q00403 (GTF2B) S65 Q12996 (CSTF3) unknown eFIP 20226668


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K178 R178 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K312 N312 Biomuta DOID:4159 / skin cancer [ cosmic ]