iPTMnet Report for P98171 (ARHGAP4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P98171 / RHG04_HUMAN
Protein Name Rho GTPase-activating protein 4
Gene Name Name: ARHGAP4
Synonyms:KIAA0131,RGC1,RHOGAP4;
Organism Homo sapiens (Human)

PRO ID PR:P98171
DAG View
PRO Name Rho GTPase-activating protein 4 (human)
Definition A Rho GTPase-activating protein 4 that is encoded in the genome of human.
Short Label hARHGAP4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P98171 (ARHGAP4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y17 Phosphorylation PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus
C34 Methylation IEDB 31844290
K69 Ubiquitination PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
Y171 Phosphorylation PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
S199 O-Glycosylation GlyGen 31637018, 32938750, 31492838, ...29351928, 34019948, 35254053, 28657654
S199 Phosphorylation PhosphoSitePlus
T202 O-Glycosylation GlyGen 31637018, 31492838, 29351928, ...34019948, 35254053, 28657654
T202 Phosphorylation PhosphoSitePlus
T203 O-Glycosylation GlyGen 31637018, 31492838, 29351928, ...34019948, 35254053, 28657654
T204 O-Glycosylation GlyGen 31637018, 31492838, 29351928, ...34019948, 35254053, 28657654
T204 Phosphorylation PhosphoSitePlus
T208 O-Glycosylation GlyGen 31637018, 31492838, 29351928, ...34019948, 35254053, 28657654
S217 Phosphorylation PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
K463 Ubiquitination PhosphoSitePlus
K473 Ubiquitination PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
Y483 Phosphorylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
K511 Ubiquitination PhosphoSitePlus
Y584 Phosphorylation PhosphoSitePlus
S587 Phosphorylation PhosphoSitePlus
T686 O-Glycosylation GlyGen 31637018, 31492838, 29351928, ...34019948, 35254053, 28657654
Y706 Phosphorylation PhosphoSitePlus
C717 Methylation IEDB 31844290
K798 Ubiquitination PhosphoSitePlus
S824 Phosphorylation PhosphoSitePlus
S842 Phosphorylation PhosphoSitePlus
S860 Phosphorylation PhosphoSitePlus   UniProt 23186163
S887 Phosphorylation PhosphoSitePlus
S899 Phosphorylation PhosphoSitePlus
S901 Phosphorylation PhosphoSitePlus   UniProt 23186163
S906 O-Glycosylation GlyGen 31637018, 31492838, 29351928, ...34019948, 35254053, 28657654
S906 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S913 O-Glycosylation GlyGen 31637018, 31492838, 29351928, ...34019948, 35254053, 28657654
S922 Phosphorylation PhosphoSitePlus
S930 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S932 Phosphorylation PhosphoSitePlus
S934 Phosphorylation PhosphoSitePlus
T941 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T942 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S408 Phosphorylation HPRD 20058876
S906 Phosphorylation HPRD 18669648
S930 Phosphorylation HPRD 18669648
T941 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K169 N169 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S199 C199 Biomuta DOID:3571 / liver cancer [ cosmic ]
S199 I199 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S199 N199 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S217 F217 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K381 N381 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S410 F410 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S419 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
S497 N497 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T686 M686 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S824 R824 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S860 P860 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S922 F922 Biomuta DOID:4159 / skin cancer [ cosmic ]
S932 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S934 F934 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T942 P942 Biomuta DOID:1324 / lung cancer [ cosmic ]