iPTMnet Report for P84243 (H3-3B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P84243 / H33_HUMAN
Protein Name Histone H3.3
Gene Name Name: H3-3B
Synonyms:H3.3A,H3F3,H3F3A;ORFNames:PP781;Synonyms:H3.3B,H3F3B;
Organism Homo sapiens (Human)

PRO ID PR:P84243
DAG View
PRO Name histone H3.3 (human)
Definition A histone H3.3 that is encoded in the genome of human.
Short Label hH3.3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P84243 (H3-3B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO
R3 Methylation UniProt 17898714, 18077460, 18079182
T4 Methylation IntAct 19834512
T4 Phosphorylation PRO   UniProt 20705812, 20929775, 19622635, ...16185088, 20953165, 15681610
K5 Acetylation PRO   UniProt 18552846, 17194708
K5 Methylation UniProt 16185088, 16267050, 16457588, ...17194708
T7 Phosphorylation PRO   UniProt 20228790
K10 Acetylation PRO   UniProt 20816089, 20972224, 19135889, ...16267050, 16457588, 16497732, 17478518, 17906200, 17403718, 18337721, 17194708, 12419248, 16544193, 16185088, 21453398
K10 Methylation UniProt 11242053, 7309716, 16267050, ...16457588, 17194708, 16185088
S11 O-Glycosylation GlyGen 21896475, 32522876, 22121020, ...34229054, 28510447
S11 Phosphorylation P51812 (RPS6KA3) , O75582 (RPS6KA5) , P06241 (FYN) , P31749 (AKT1) , Q15418 (RPS6KA1) , Q96GD4 (AURKB) , P17612 (PRKACA) HPRD   neXtProt   phospho.ELM   PRO   Signor   UniProt 15537652, 10911986, 12560483, ...10436156, 12677454, 11562345, 12588998, 10464286, 14625384, 18508628, 18256527, 11856369, 14722118, 14583461, 16651411, 16185088, 12529330, 15994958, 12773393, 15851689, 15681610
T12 Phosphorylation O14757 (CHEK1) PRO   Signor   UniProt 18243098, 12560483, 18066052, ...22901803
K15 Acetylation PRO   UniProt 16267050, 7309716, 16497732, ...16678094, 17194708, 16185088, 12419248
R18 Methylation UniProt 15345777, 15471871, 16497732
K19 Acetylation PRO   UniProt 20978174, 18552846, 16267050, ...35939806, 15988529, 17194708, 20841388, 19349354, 18953329
K19 Methylation UniProt 16267050, 17194708
K24 Acetylation PRO   UniProt 21164480, 16267050, 7309716, ...17194708
K24 Methylation UniProt 17194708
K28 Acetylation PRO   UniProt 18552846, 16267050, 19608861, ...20385584, 17194708
K28 Methylation UniProt 16185088, 16267050, 7309716, ...17194708, 24129315
S29 Phosphorylation P17612 (PRKACA) , O75582 (RPS6KA5) , P45984 (MAPK9) HPRD   neXtProt   phospho.ELM   PRO   Signor   UniProt 20068231, 11856369, 10464286, ...15684425, 18508628, 19007248, 15851689, 14722118, 11278789, 16185088, 17924679, 15681610, 21282660
S32 Phosphorylation phospho.ELM   PRO   UniProt 16185088, 15851689
T33 O-Glycosylation GlyGen 22371497
K37 Acetylation PRO   PhosphoSitePlus   UniProt 17189264, 18552846, 17194708
K37 Methylation PhosphoSitePlus   UniProt 16185088, 16267050, 7309716, ...17194708
K37 Ubiquitination PhosphoSitePlus
Y42 Phosphorylation O60674 (JAK2) neXtProt   PRO   UniProt 19783980
T46 Phosphorylation PRO 19363025
K57 Acetylation PRO   UniProt 20587414, 19625767, 19270680, ...17194708
K57 Methylation UniProt 22387026, 17194708
S58 Phosphorylation UniProt 20850016
K65 Methylation UniProt 16267050, 17194708
K80 Acetylation PRO   UniProt 17194708
K80 Methylation UniProt 15525939, 16267050, 17194708
T81 Phosphorylation UniProt 20850016
S87 Phosphorylation HPRD   UniProt 20068231, 24275569
C111 S-Nitrosylation dbSNO 25040305
K116 Acetylation UniProt 19520870
K123 Acetylation UniProt 19520870, 23415232
K123 Methylation UniProt 16267050, 17194708


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R3 C3 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
R3 G3 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R3 P3 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K5 M5 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc ]
T12 A12 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K15 N15 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
R18 G18 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K28 M28 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
K28 N28 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K28 E28 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K28 R28 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S29 T29 Biomuta DOID:3565 / meningioma [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T33 I33 Biomuta DOID:1612 / breast cancer [ cosmic ]
K37 R37 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K37 N37 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K37 M37 Biomuta DOID:184 / bone cancer [ cosmic ]
T46 A46 Biomuta DOID:3571 / liver cancer [ cosmic ]
K57 * Biomuta DOID:1319 / brain cancer [ cosmic ]
K65 T65 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]