iPTMnet Report for P78562 (PHEX)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P78562 / PHEX_HUMAN
Protein Name Phosphate-regulating neutral endopeptidase PHEX
Gene Name Name: PHEX
Synonyms:PEX;
Organism Homo sapiens (Human)

PRO ID PR:P78562
DAG View
PRO Name phosphate-regulating neutral endopeptidase PHEX (human)
Definition A phosphate-regulating neutral endopeptidase PHEX that is encoded in the genome of human.
Short Label hPHEX
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P78562 (PHEX) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T5 Phosphorylation PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus
S8 Phosphorylation PhosphoSitePlus
T11 Phosphorylation PhosphoSitePlus
S122 Phosphorylation IEDB 35494241
T129 Phosphorylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
T190 Phosphorylation HPRD   PhosphoSitePlus 18491316
T193 Phosphorylation HPRD   PhosphoSitePlus 18491316
N238 N-Glycosylation GlyGen 24190977
Y346 Phosphorylation PhosphoSitePlus
S623 Phosphorylation PhosphoSitePlus
T639 Phosphorylation PhosphoSitePlus
N736 N-Glycosylation GlyGen 24190977


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S8 N8 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T129 I129 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T190 I190 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T193 M193 Biomuta DOID:9256 / colorectal cancer [ cosmic ]