iPTMnet Report for P78371 (CCT2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P78371 / TCPB_HUMAN
Protein Name T-complex protein 1 subunit beta
Gene Name Name: CCT2
Synonyms:99D8.1,CCTB;
Organism Homo sapiens (Human)

PRO ID PR:P78371
DAG View
PRO Name T-complex protein 1 subunit beta (human)
Definition A T-complex protein 1 subunit beta that is encoded in the genome of human.
Short Label hCCT2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P78371 (CCT2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
A2 Acetylation UniProt 19413330, 21406692, 22223895, ...22814378, 20068231
S3 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
S5 Phosphorylation PhosphoSitePlus
K13 Acetylation PhosphoSitePlus   UniProt 19608861
K13 Ubiquitination PhosphoSitePlus
T23 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus   UniProt 23186163
K72 Ubiquitination PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K120 Acetylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
K154 Acetylation PhosphoSitePlus   UniProt 19608861
K154 Ubiquitination PhosphoSitePlus
T165 Phosphorylation PhosphoSitePlus
T166 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
K181 Acetylation PhosphoSitePlus   UniProt 19608861
K191 Acetylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
K204 Acetylation PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
Y213 Phosphorylation PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
K223 Sumoylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
T242 Phosphorylation PhosphoSitePlus
T246 Phosphorylation PhosphoSitePlus
K248 Acetylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
S254 Phosphorylation PhosphoSitePlus
S260 Phosphorylation P31749 (AKT1) , Q15418 (RPS6KA1) , P23443 (RPS6KB1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 21440620, 19332537
T261 Phosphorylation PhosphoSitePlus   UniProt 21406692
K263 Ubiquitination PhosphoSitePlus
K272 Acetylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
K284 Acetylation PhosphoSitePlus
K284 Methylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
Y297 Phosphorylation PhosphoSitePlus
K342 Acetylation PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
T379 Phosphorylation PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
C395 Methylation IEDB 31844290
K402 Ubiquitination PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
R427 Methylation PhosphoSitePlus
T428 Phosphorylation PhosphoSitePlus
K431 Acetylation PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
Y439 Phosphorylation PhosphoSitePlus
K441 Acetylation PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
T448 Phosphorylation PhosphoSitePlus
Y456 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
C535 S-Nitrosylation dbSNO 26338901
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation HPRD 20068231
S115 Phosphorylation HPRD 20068231
S143 Phosphorylation HPRD 20068231
S150 Phosphorylation HPRD 20068231
S260 Phosphorylation HPRD 20166139, 18212344, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S3 F3 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K119 T119 Biomuta DOID:184 / bone cancer [ cosmic ]
S150 C150 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S150 F150 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S169 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K170 E170 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K181 E181 Biomuta DOID:1324 / lung cancer [ cosmic ]
T246 S246 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S260 C260 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K347 T347 Biomuta DOID:363 / uterine cancer [ icgc ]
S389 L389 Biomuta DOID:4159 / skin cancer [ cosmic ]
T428 I428 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S438 C438 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y456 H456 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y456 C456 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S458 N458 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
C535 F535 Biomuta DOID:3571 / liver cancer [ cosmic ]