iPTMnet Report for P78352 (DLG4)
Protein Information
| UniProt AC / UniProt ID | P78352 / DLG4_HUMAN |
| Protein Name | Disks large homolog 4 |
| Gene Name | Name: DLG4 Synonyms:PSD95; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P78352 |
| PRO Name | disks large homolog 4 (human) |
| Definition | A disks large homolog 4 that is encoded in the genome of human. |
| Short Label | hDLG4 |
| Category | organism-gene |
DAG ViewP78352 (DLG4) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T8 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T19 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S25 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S73 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P | 17156196, 19081375 | ||
| S78 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S116 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S142 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y147 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T192 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y236 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y240 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T287 | Phosphorylation | score3 | neXtProt RLIMS-P | 14741046 | ||
| T287 | Phosphorylation | O15264 (MAPK13) | score2 | neXtProt | 14741046 | |
| T287 | Phosphorylation | P28482 (MAPK1) | score2 | neXtProt | 14741046 | |
| T287 | Phosphorylation | P53778 (MAPK12) | score2 | neXtProt | 14741046 | |
| S290 | Phosphorylation | score3 | neXtProt RLIMS-P | 14741046 | ||
| S290 | Phosphorylation | P53778 (MAPK12) | score2 | neXtProt | 14741046 | |
| S295 | Phosphorylation | score3 | neXtProt PhosphoSitePlus RLIMS-P | 17988632 | ||
| S295 | Phosphorylation | P45983 (MAPK8) | score2 | neXtProt | 17988632 | |
| Y397 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 21965656 | ||
| K403 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S425 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y523 | Phosphorylation | score4 | neXtProt PhosphoSitePlus RLIMS-P Signor | 24981431, 22709448, 18721130 | ||
| Y523 | Phosphorylation | P06241 (FYN) | score3 | PhosphoSitePlus Signor | 18721130 | |
| Y523 | Phosphorylation | P12931 (SRC) | score4 | neXtProt PhosphoSitePlus Signor | 24981431, 18721130 | |
| S561 | Phosphorylation | score4 | neXtProt PhosphoSitePlus RLIMS-P | 28790172, 22807451 | ||
| S561 | Phosphorylation | Q7KZI7 (MARK2) | score3 | neXtProt PhosphoSitePlus | 22807451 | |
| Y573 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y701 | Phosphorylation | score1 | PhosphoSitePlus |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | P78352 (DLG4) | Y523 | Q14289 (PTK2B) | decreased_association | eFIP | 24981431 | |
| Phosphorylation | Q15768 (EFNB3) | S332 | P78352 (DLG4) | inhibited_association | eFIP | 26479588 |
Proteoform PPIs
|
Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:P63142-1 (rKCNA2/iso:1) | Interaction | PR:P78352 (hDLG4) | PRO | 17959782 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T19 | M19 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| S25 | R25 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| S116 | I116 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S142 | F142 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S290 | F290 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| Y573 | N573 | Biomuta | DOID:263 / kidney cancer [ cosmic ] |
