iPTMnet Report for P78324 (SIRPA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P78324 / SHPS1_HUMAN
Protein Name Tyrosine-protein phosphatase non-receptor type substrate 1 precursor
Gene Name Name: SIRPA
Synonyms:BIT,MFR,MYD1,PTPNS1,SHPS1,SIRP;
Organism Homo sapiens (Human)

PRO ID PR:P78324
DAG View
PRO Name tyrosine-protein phosphatase non-receptor type substrate 1 (human)
Definition A tyrosine-protein phosphatase non-receptor type substrate 1 that is encoded in the genome of human.
Short Label hSIRPA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P78324 (SIRPA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K83 Ubiquitination PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
N110 N-Glycosylation GlyGen 23090970, 29741879, 24190977
K183 Ubiquitination PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
N245 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 24190977, ...29741879
S247 O-Glycosylation GlyGen 28657654
N267 N-Glycosylation GlyGen 24190977
N270 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19159218, ...24190977
T272 O-Glycosylation GlyGen 28657654
N290 N-Glycosylation GlyGen 24190977
N292 N-Glycosylation GlyGen   UniProt 23090970, 23345538, 19159218, ...24190977
Y310 Phosphorylation IEDB 35494241
T408 Phosphorylation PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
T428 Phosphorylation PhosphoSitePlus
Y429 Phosphorylation P42679 (MATK) neXtProt   PhosphoSitePlus 17999719, 21799000
K436 Ubiquitination PhosphoSitePlus
Y453 Phosphorylation P42679 (MATK) neXtProt   PhosphoSitePlus 17999719, 21799000
S464 Phosphorylation PhosphoSitePlus
T467 Phosphorylation PhosphoSitePlus
T469 Phosphorylation PhosphoSitePlus
Y470 Phosphorylation P42679 (MATK) , P08069 (IGF1R) neXtProt   PhosphoSitePlus 17999719, 21799000
K483 Acetylation PhosphoSitePlus
S494 O-Glycosylation GlyGen 28657654
S494 Phosphorylation PhosphoSitePlus
Y496 Phosphorylation P42679 (MATK) , P08069 (IGF1R) neXtProt   PhosphoSitePlus   UniProt 17999719, 21799000, 24275569
Site PTM Type PTM Enzyme Score Source PMID
N292 N-Glycosylation PRO 23345538
Y429 Phosphorylation PRO
Y453 Phosphorylation PRO
Y470 Phosphorylation PRO
Y496 Phosphorylation O60674 (JAK2) HPRD   PRO 17016520, 17389395, 10842184


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000026555 (hSIRPA/iso:1/SigPep-/Phos:1) pY429,pY453,pY470,pY496 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N110 D110 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S192 L192 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S204 R204 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T408 A408 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S494 * Biomuta DOID:4159 / skin cancer [ cosmic ]