iPTMnet Report P68871 HBB

Protein Information

UniProt AC / UniProt ID	P68871 / HBB_HUMAN
Protein Name	Hemoglobin subunit beta
Gene Name	Name: HBB
Organism	Homo sapiens (Human)

PRO ID	PR:P68871 DAG View
PRO Name	hemoglobin subunit beta (human)
Definition	A hemoglobin subunit beta that is encoded in the genome of human.
Short Label	hHBB
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P68871 (HBB) as Substrate

P68871

Expanded View

Site	PTM Type	Score	Source	PMID
T5	Phosphorylation	score2	HPRD PhosphoSitePlus	20166139
K9	Acetylation	score1	PhosphoSitePlus
S10	Phosphorylation	score2	HPRD PhosphoSitePlus UniProt	20166139, 24275569
T13	Phosphorylation	score2	PhosphoSitePlus UniProt	24275569
K18	Acetylation	score1	PhosphoSitePlus
K18	Methylation	score1	PhosphoSitePlus
Y36	Phosphorylation	score1	PhosphoSitePlus
T39	Phosphorylation	score1	PhosphoSitePlus
S45	O-Glycosylation	score1	GlyGen	30459171
S45	Phosphorylation	score2	HPRD PhosphoSitePlus UniProt	20166139, 24275569
S50	O-Glycosylation	score2	GlyGen PhosphoSitePlus	26374642, 33214551, 18984734, ...34019948
S50	Phosphorylation	score2	HPRD PhosphoSitePlus	20166139
T51	Phosphorylation	score2	PhosphoSitePlus UniProt	24275569
K60	Acetylation	score3	PhosphoSitePlus UniProt	4531009
K62	Acetylation	score1	PhosphoSitePlus
K66	Acetylation	score1	PhosphoSitePlus
K67	Acetylation	score1	PhosphoSitePlus
S73	O-Glycosylation	score2	GlyGen PhosphoSitePlus	26374642, 33214551, 18984734, ...34019948
S73	Phosphorylation	score2	HPRD PhosphoSitePlus	20166139
K83	Acetylation	score3	PhosphoSitePlus UniProt	4531009
T85	O-Glycosylation	score2	GlyGen PhosphoSitePlus	26374642, 33214551, 18984734, ...34019948
T88	Phosphorylation	score2	PhosphoSitePlus UniProt	24275569
S90	Phosphorylation	score1	PhosphoSitePlus
C94	S-Nitrosylation	score2	dbSNO	8637569, 9843411, 25040305
K96	Acetylation	score1	PhosphoSitePlus
C113	S-Nitrosylation	score0	dbSNO	25040305
K121	Acetylation	score1	PhosphoSitePlus
T124	Phosphorylation	score1	PhosphoSitePlus
Y131	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus	18083107
K133	Acetylation	score1	PhosphoSitePlus
K145	Acetylation	score3	PhosphoSitePlus UniProt	4531009
Y146	Phosphorylation	score1	PhosphoSitePlus

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
T5	A5	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]
K9	N9	Biomuta	[ cosmic ]
K9	*	Biomuta	DOID:3571 / liver cancer [ cosmic ]
K18	T18	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S45	Y45	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S45	F45	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S50	P50	Biomuta	DOID:3571 / liver cancer [ cosmic ]
T51	I51	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
K67	N67	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S73	G73	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
K83	N83	Biomuta	DOID:10283 / prostate cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
T88	P88	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K121	Q121	Biomuta	DOID:1324 / lung cancer [ cosmic ]
Y131	C131	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K133	R133	Biomuta	DOID:4159 / skin cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P68871 (HBB)

Protein Information

Interactive Sequence View

P68871 (HBB) as Substrate

PTM sites affected in variants