iPTMnet Report for P68366 (TUBA4A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P68366 / TBA4A_HUMAN
Protein Name Tubulin alpha-4A chain
Gene Name Name: TUBA4A
Synonyms:TUBA1;
Organism Homo sapiens (Human)

PRO ID PR:P68366
DAG View
PRO Name tubulin alpha-4A chain (human)
Definition A tubulin alpha-4A chain that is encoded in the genome of human.
Short Label hTUBA4A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P68366 (TUBA4A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation phospho.ELM   PhosphoSitePlus 15345747
Y24 Phosphorylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
K40 Acetylation PhosphoSitePlus   UniProt 24906155
T41 Phosphorylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus   UniProt 18669648
C54 S-Nitrosylation dbSNO 20140087
K60 Ubiquitination PhosphoSitePlus
T73 Phosphorylation PhosphoSitePlus
T94 Phosphorylation PhosphoSitePlus
K96 Acetylation PhosphoSitePlus
K96 Sumoylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
Y103 Phosphorylation PhosphoSitePlus
Y108 Phosphorylation PhosphoSitePlus
T109 Phosphorylation PhosphoSitePlus
K112 Acetylation PhosphoSitePlus
K112 Sumoylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K124 Methylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
Y161 Phosphorylation PhosphoSitePlus
K163 Acetylation PhosphoSitePlus
K163 Methylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
Y172 Phosphorylation PhosphoSitePlus
Y185 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
T190 Phosphorylation PhosphoSitePlus
T191 Phosphorylation PhosphoSitePlus
T193 Phosphorylation PhosphoSitePlus
T194 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
T223 Phosphorylation PhosphoSitePlus
Y224 Phosphorylation PhosphoSitePlus
T225 Phosphorylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
T239 Phosphorylation PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
T253 Phosphorylation PhosphoSitePlus
T257 Phosphorylation PhosphoSitePlus
Y262 Phosphorylation PhosphoSitePlus
T271 Phosphorylation PhosphoSitePlus
Y272 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455, 15659558
S277 Phosphorylation PhosphoSitePlus
K280 Acetylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
Y282 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
T292 Phosphorylation PhosphoSitePlus
C295 S-Nitrosylation dbSNO 20140087
K304 Ubiquitination PhosphoSitePlus
K311 Acetylation PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
Y312 Phosphorylation PhosphoSitePlus
Y319 Phosphorylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
K336 Sumoylation PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
R339 Methylation PhosphoSitePlus
S340 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
C347 S-Nitrosylation dbSNO 19483679, 20140087
T349 Phosphorylation PhosphoSitePlus
K352 Acetylation PhosphoSitePlus
K352 Sumoylation PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
Y357 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
T361 Phosphorylation PhosphoSitePlus
K370 Acetylation PhosphoSitePlus
K370 Sumoylation PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
C376 S-Nitrosylation dbSNO 19483679, 20140087
S379 Phosphorylation PhosphoSitePlus
K394 Acetylation PhosphoSitePlus
K394 Sumoylation PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
Y399 Phosphorylation PhosphoSitePlus
K401 Acetylation PhosphoSitePlus
K401 Sumoylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
Y408 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
Y432 Phosphorylation P43405 (SYK) PhosphoSitePlus   Signor 9490415
S439 O-Glycosylation GlyGen 30444036, 30397120, 34725712, ...33214551, 30796923, 34019948, 29351928
S439 Phosphorylation phospho.ELM   PhosphoSitePlus 18088087
Y440 Phosphorylation phospho.ELM   PhosphoSitePlus 18088087
Site PTM Type PTM Enzyme Score Source PMID
S48 Phosphorylation HPRD 18691976, 18669648, 15345747, ...20068231
T50 Phosphorylation HPRD 18669648
S158 Phosphorylation HPRD 19691289
Y161 Phosphorylation HPRD 17924679
S232 Phosphorylation HPRD 20068231
T271 Phosphorylation HPRD 18691976
Y272 Phosphorylation HPRD 15659558
S340 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
Y357 Phosphorylation HPRD 15592455
S379 Phosphorylation HPRD 19664995
Y432 Phosphorylation P43405 (SYK) HPRD 8617742
S439 Phosphorylation HPRD 18088087
Y440 Phosphorylation HPRD 18088087


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T41 I41 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T50 P50 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T94 N94 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y108 D108 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y108 C108 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T109 A109 Biomuta DOID:3571 / liver cancer [ cosmic ]
S158 C158 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y161 C161 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
K163 E163 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K163 N163 Biomuta DOID:363 / uterine cancer [ icgc ]
Y172 N172 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y172 H172 Biomuta DOID:263 / kidney cancer [ cosmic ]
S187 F187 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y210 C210 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S236 F236 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S237 F237 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S277 C277 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K280 N280 Biomuta DOID:1324 / lung cancer [ cosmic ]
S287 L287 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K326 R326 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K338 E338 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R339 H339 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
R339 C339 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S340 R340 Biomuta DOID:3571 / liver cancer [ cosmic ]
K394 * Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]