iPTMnet Report for P67936 (TPM4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P67936 / TPM4_HUMAN
Protein Name Tropomyosin alpha-4 chain
Gene Name Name: TPM4
Organism Homo sapiens (Human)

PRO ID PR:P67936
DAG View
PRO Name tropomyosin alpha-4 chain (human)
Definition A tropomyosin alpha-4 chain that is encoded in the genome of human.
Short Label hTPM4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P67936 (TPM4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
S6 Phosphorylation PhosphoSitePlus
K11 Acetylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
R27 Methylation PhosphoSitePlus
T72 Phosphorylation PhosphoSitePlus
K76 Acetylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
K82 Acetylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
K92 Sumoylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
K116 Acetylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
R124 Methylation PhosphoSitePlus
K125 Acetylation PhosphoSitePlus
Y126 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K132 Acetylation PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
C154 S-Nitrosylation dbSNO 20140087
K162 Ubiquitination PhosphoSitePlus
T165 Phosphorylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
K177 Acetylation PhosphoSitePlus   UniProt 19608861
K177 Ubiquitination PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
K184 Acetylation PhosphoSitePlus
K184 Methylation PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
Y185 Phosphorylation PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
T201 Phosphorylation PhosphoSitePlus
K212 Acetylation PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
K215 Acetylation PhosphoSitePlus   UniProt 19608861
K215 Ubiquitination PhosphoSitePlus
T216 Phosphorylation PhosphoSitePlus   UniProt 23186163
K223 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
T237 Phosphorylation PhosphoSitePlus
T241 O-Glycosylation GlyGen 35008409, 33214551, 35132862, ...34019948
T241 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
K12 Ubiquitination PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T72 M72 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R124 S124 Biomuta DOID:4159 / skin cancer [ cosmic ]
K162 E162 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
T165 I165 Biomuta DOID:4159 / skin cancer [ cosmic ]
S170 Y170 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y185 C185 Biomuta DOID:4159 / skin cancer [ cosmic ]