iPTMnet Report for P67775 (PPP2CA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P67775 / PP2AA_HUMAN
Protein Name Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Gene Name Name: PPP2CA
Organism Homo sapiens (Human)

PRO ID PR:P67775
DAG View
PRO Name serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (human)
Definition A serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform that is encoded in the genome of human.
Short Label hPPP2CA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P67775 (PPP2CA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K4 Acetylation PhosphoSitePlus
K4 Sumoylation PhosphoSitePlus
K4 Ubiquitination PhosphoSitePlus
K8 Sumoylation PhosphoSitePlus
K8 Ubiquitination PhosphoSitePlus
C20 Methylation IEDB 31844290
K21 Ubiquitination PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
K29 Acetylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
K41 Acetylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
T78 Phosphorylation PhosphoSitePlus
Y86 Phosphorylation PhosphoSitePlus
Y127 Phosphorylation PhosphoSitePlus
K136 Acetylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
Y248 Phosphorylation PhosphoSitePlus
Y265 Phosphorylation PhosphoSitePlus
C266 S-Nitrosylation dbSNO 19483679
K283 Ubiquitination PhosphoSitePlus
Y284 Phosphorylation PhosphoSitePlus
R295 Methylation PhosphoSitePlus
T304 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 17635907, 10978272, 17394530
Y307 Phosphorylation P06239 (LCK) , P00533 (EGFR) , P06213 (INSR) , P12931 (SRC) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 33162896, 32977471, 23796501, ...11996003, 28057023, 1325671, 16286244, 27013170, 20450893, 24632852, 17635907, 20636478, 22299660, 27012437, 17394530, 28402257, 27489114, 24395787
L309 Methylation IntAct   PhosphoSitePlus 17055435


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048884 (hPPP2CA/Phos:1) pY307 PRO


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q5FBB7 (hSGO1) Interaction PR:P67775 (hPPP2CA) PRO 16580887


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K8 M8 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S26 F26 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
Y248 C248 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y265 N265 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
Y265 F265 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]