iPTMnet Report for P63261 (ACTG1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P63261 / ACTG_HUMAN
Protein Name Actin, cytoplasmic 2
Gene Name Name: ACTG1
Synonyms:ACTG;
Organism Homo sapiens (Human)

PRO ID PR:P63261
DAG View
PRO Name actin, cytoplasmic 2 (human)
Definition An actin, cytoplasmic 2 that is encoded in the genome of human.
Short Label hACTG1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P63261 (ACTG1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO   UniProt 22814378, 22223895, 36173861
E2 Acetylation UniProt 19413330, 22223895, 29581253, ...22814378, 30028079, 25944712
S14 Phosphorylation PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
R28 Methylation PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
K50 Acetylation PhosphoSitePlus
K50 Methylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
Y53 Phosphorylation PhosphoSitePlus
S60 O-Glycosylation GlyGen 16408927, 34846842, 36580660, ...23271734, 30379171, 26374642, 30397120, 29351928, 34019948, 35083852, 35289036, 28510447
S60 Phosphorylation PhosphoSitePlus
K61 Acetylation PhosphoSitePlus
K61 Sumoylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
T66 Phosphorylation PhosphoSitePlus
K68 Acetylation PhosphoSitePlus
K68 Methylation PhosphoSitePlus
Y69 Phosphorylation PhosphoSitePlus
E72 Methylation IEDB 29786170
H73 Methylation IEDB 29786170
T77 Phosphorylation PhosphoSitePlus
K84 Methylation UniProt 23673617
K84 Sumoylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
T89 Phosphorylation PhosphoSitePlus
Y91 Phosphorylation PhosphoSitePlus
T106 Phosphorylation PhosphoSitePlus
K113 Acetylation PhosphoSitePlus
K113 Sumoylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
T120 Phosphorylation PhosphoSitePlus
Y143 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
T160 Phosphorylation PhosphoSitePlus
T162 Phosphorylation PhosphoSitePlus
Y166 Phosphorylation PhosphoSitePlus
Y169 Phosphorylation PhosphoSitePlus
T186 Phosphorylation PhosphoSitePlus
Y188 Phosphorylation PhosphoSitePlus
K191 Acetylation PhosphoSitePlus
K191 Methylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
T194 Phosphorylation PhosphoSitePlus
Y198 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S199 Phosphorylation PhosphoSitePlus
T201 Phosphorylation HPRD   PhosphoSitePlus 20068231
T202 Phosphorylation PhosphoSitePlus
T203 Phosphorylation PhosphoSitePlus
K213 Acetylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
K215 Acetylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
Y218 Phosphorylation HPRD   PhosphoSitePlus 18452278
T229 Phosphorylation PhosphoSitePlus
S233 Phosphorylation HPRD   PhosphoSitePlus 20068231
S235 Phosphorylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
S239 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y240 Phosphorylation PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus
S265 O-Glycosylation GlyGen 16408927, 34846842, 36580660, ...23271734, 30379171, 26374642, 30397120, 29351928, 34019948, 35083852, 35289036, 28510447
S265 Phosphorylation PhosphoSitePlus
S271 O-Glycosylation GlyGen 16408927, 34846842, 36580660, ...23271734, 30379171, 26374642, 30397120, 29351928, 34019948, 35083852, 35289036, 28510447
S271 Phosphorylation PhosphoSitePlus
T277 O-Glycosylation GlyGen 16408927, 34846842, 36580660, ...23271734, 30379171, 26374642, 30397120, 29351928, 34019948, 35083852, 35289036, 28510447
T278 O-Glycosylation GlyGen 16408927, 34846842, 36580660, ...23271734, 30379171, 26374642, 30397120, 29351928, 34019948, 35083852, 35289036, 28510447
S281 O-Glycosylation GlyGen 16408927, 34846842, 36580660, ...23271734, 30379171, 26374642, 30397120, 29351928, 34019948, 35083852, 35289036, 28510447
S281 Phosphorylation IEDB 35494241
K284 Ubiquitination PhosphoSitePlus
K291 Sumoylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
Y294 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T297 O-Glycosylation GlyGen 16408927, 34846842, 36580660, ...23271734, 30379171, 26374642, 30397120, 29351928, 34019948, 35083852, 35289036, 28510447
T297 Phosphorylation HPRD   PhosphoSitePlus 20068231
S300 O-Glycosylation GlyGen 16408927, 34846842, 36580660, ...23271734, 30379171, 26374642, 30397120, 29351928, 34019948, 35083852, 35289036, 28510447
S300 Phosphorylation PhosphoSitePlus
T303 O-Glycosylation GlyGen 16408927, 34846842, 36580660, ...23271734, 30379171, 26374642, 30397120, 29351928, 34019948, 35083852, 35289036, 28510447
T303 Phosphorylation PhosphoSitePlus
T304 Phosphorylation PhosphoSitePlus
Y306 Phosphorylation PhosphoSitePlus
K315 Acetylation PhosphoSitePlus
K315 Sumoylation PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
T318 Phosphorylation PhosphoSitePlus
S323 Phosphorylation HPRD   PhosphoSitePlus 20068231
T324 Phosphorylation PhosphoSitePlus
K326 Acetylation PhosphoSitePlus
K326 Methylation PhosphoSitePlus
K326 Sumoylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
K328 Acetylation PhosphoSitePlus
K328 Sumoylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K336 Sumoylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
Y362 Phosphorylation PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036200 (hACTG1/Ac:1) acM1 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R28 L28 Biomuta DOID:1612 / breast cancer [ icgc ]
S33 F33 Biomuta DOID:1324 / lung cancer [ icgc ]
K84 N84 Biomuta DOID:1612 / breast cancer [ icgc ]
T89 I89 Biomuta DOID:1319 / brain cancer [ icgc ]