iPTMnet Report for P63151 (PPP2R2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P63151 / 2ABA_HUMAN
Protein Name Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Gene Name Name: PPP2R2A
Organism Homo sapiens (Human)

PRO ID PR:P63151
DAG View
PRO Name serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (human)
Definition A serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform that is encoded in the genome of human.
Short Label hPPP2R2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P63151 (PPP2R2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895
K62 Acetylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
R68 Methylation PhosphoSitePlus
K88 Acetylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K98 Acetylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
C239 Methylation IEDB 31844290
S266 Phosphorylation PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
R278 Methylation PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
T359 Phosphorylation PhosphoSitePlus
T378 Phosphorylation PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
S400 Phosphorylation Q13315 (ATM) neXtProt 22466704
K402 Acetylation PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
S409 Phosphorylation PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
Y440 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S167 Phosphorylation HPRD 20068231
T378 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K95 M95 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K105 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K129 T129 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
C239 S239 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S266 Y266 Biomuta DOID:1319 / brain cancer [ cosmic ]
K292 N292 Biomuta DOID:4159 / skin cancer [ cosmic ]
K402 N402 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S409 I409 Biomuta DOID:363 / uterine cancer [ icgc ]
K417 T417 Biomuta DOID:9256 / colorectal cancer [ icgc ]