iPTMnet Report for P62807 (H2BC10)
Protein Information
UniProt AC / UniProt ID | P62807 / H2B1C_HUMAN |
Protein Name | Histone H2B type 1-C/E/F/G/I |
Gene Name | Name: H2BC10 Synonyms:H2BFL,HIST1H2BC;Synonyms:H2BFH,HIST1H2BE;Synonyms:H2BFG,HIST1H2BF;Synonyms:H2BFA,HIST1H2BG;Synonyms:H2BFK,HIST1H2BI; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P62807 |
PRO Name | histone H2B type 1-C/E/F/G/I (human) |
Definition | A histone H2B type 1-C/E/F/G/I that is encoded in the genome of human. |
Short Label | hH2BC[4/6/7/8/10] |
Category | organism-gene |
P62807 (H2BC10) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
M1 | Acetylation | score1 | PRO | |||
K6 | Acetylation | score2 | PRO UniProt | 18552846, 16283522, 16627869 | ||
S7 | Phosphorylation | score0 | HPRD | 19413330 | ||
K12 | Acetylation | score2 | PhosphoSitePlus UniProt | 16627869 | ||
K13 | Acetylation | score2 | PRO UniProt | 18552846, 16283522, 20693536, ... | ||
S15 | Phosphorylation | score4 | phospho.ELM PRO UniProt | 12757711, 1137958 | ||
K16 | Acetylation | score2 | PRO PhosphoSitePlus UniProt | 16283522, 19883641, 16627869 | ||
K17 | Acetylation | score2 | PRO UniProt | 20693536, 16627869 | ||
K21 | Acetylation | score2 | PRO UniProt | 18552846, 16627869, 16283522 | ||
K24 | Acetylation | score1 | PhosphoSitePlus | |||
S33 | Phosphorylation | score2 | phospho.ELM | 192223 | ||
K35 | Ubiquitination | score1 | UniProt | 21726816 | ||
S37 | Phosphorylation | score2 | phospho.ELM | 192223 | ||
K47 | Acetylation | score1 | PRO | 20693536 | ||
K47 | Methylation | score1 | UniProt | 16627869 | ||
S56 | Phosphorylation | score1 | PhosphoSitePlus | |||
K58 | Methylation | score1 | UniProt | 16627869 | ||
K109 | Methylation | score1 | UniProt | 16627869 | ||
S113 | O-Glycosylation | score4 | GlyGen UniProt | 26408091, 32522876, 26359231, ... | ||
K121 | Acetylation | score1 | PRO | 18552846 | ||
K121 | Ubiquitination | score2 | PRO UniProt | 18400894, 16307923, 16627869, ... |
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000036257 (hH2BC[4/6/7/8/10]/Ac:1) | acM1 | PRO | |||
PR:000045035 (hH2BC[4/6/7/8/10]/InitMet-/Ac:1) | acK13 | PRO | 16283522, 18552846, 20693536 | ||
PR:000045036 (hH2BC[4/6/7/8/10]/InitMet-/Phos:1) | pS15 | PRO | 12757711 | ||
PR:000045037 (hH2BC[4/6/7/8/10]/InitMet-/Ac:2) | acK21 | PRO | 16283522, 18552846 | ||
PR:000045039 (hH2BC[4/6/7/8/10]/InitMet-/Ubiq:1) | ubK121 | PRO | 16307923, 16713563, 18400894, ... | ||
PR:000045040 (hH2BC[4/6/7/8/10]/InitMet-/Ac:3) | acK17 | PRO | 20693536 | ||
PR:000045041 (hH2BC[4/6/7/8/10]/InitMet-/Ac:4) | acK6 | PRO | 18552846 | ||
PR:000045043 (hH2BC[4/6/7/8/10]/InitMet-/Ac:5) | acK47 | PRO | 20693536 | ||
PR:000045044 (hH2BC[4/6/7/8/10]/InitMet-/Ac:6) | acK121 | PRO | 18552846 | ||
PR:000045045 (hH2BC[4/6/7/8/10]/InitMet-/Ac:7) | acK16 | PRO | 19883641 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S7 | P7 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
K12 | N12 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
K12 | R12 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
K16 | N16 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
K17 | N17 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
K47 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S56 | L56 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
K58 | N58 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |