iPTMnet Report for P62805 (H4C16)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P62805 / H4_HUMAN
Protein Name Histone H4
Gene Name Name: H4C16
Synonyms:H4/A,H4FA,HIST1H4A;Synonyms:H4/I,H4FI,HIST1H4B;Synonyms:H4/G,H4FG,HIST1H4C;Synonyms:H4/B,H4FB,HIST1H4D;Synonyms:H4/J,H4FJ,HIST1H4E;Synonyms:H4/C,H4FC,HIST1H4F;Synonyms:H4/H,H4FH,HIST1H4H;Synonyms:H4/M,H4FM,HIST1H4I;Synonyms:H4/E,H4FE,HIST1H4J;Synonyms:H4/D,H4FD,HIST1H4K;Synonyms:H4/K,H4FK,HIST1H4L;Synonyms:H4/N,H4F2,H4FN,HIST2H4,HIST2H4A;Synonyms:H4/O,H4FO,HIST2H4B;Synonyms:H4-16,HIST4H4;
Organism Homo sapiens (Human)

PRO ID PR:P62805
DAG View
PRO Name histone H4 (human)
Definition A histone H4 that is encoded in the genome of human.
Short Label hH4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P62805 (H4C16) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 17967882
S2 Phosphorylation phospho.ELM   PRO   UniProt 15823538, 1956339, 17967882
R4 Methylation UniProt 11448779, 11387442, 15345777
K6 Acetylation PRO   UniProt 21272292, 7664735, 18552846, ...8343956, 16387653, 2474456, 19608861
K9 Acetylation PRO   UniProt 19608861, 7664735, 18552846, ...16387653, 2474456, 10958685
K13 Acetylation PRO   UniProt 19608861, 7664735, 18552846, ...16387653, 10958685, 2474456, 17967882
K13 Methylation UniProt 31061526
K17 Acetylation PRO   UniProt 21272292, 7664735, 15469825, ...18552846, 15765097, 20525793, 19608861, 2474456, 20479123, 17967882
K21 Methylation UniProt 15964846, 27338793, 12086618, ...17967882
K32 Acetylation UniProt 19608861
S48 O-Glycosylation GlyGen 33214551, 34725712, 30397120, ...26374642, 32522876, 30444036, 21045127, 34019948, 35083852, 32119511, 22121020, 34229054
S48 Phosphorylation Q13177 (PAK2) HPRD   neXtProt   phospho.ELM   UniProt 21406692, 23186163, 17081983, ...21724829, 20058876, 19007248, 198400, 18669648, 24275569, 20166139, 19690332, 20068231, 18212344
Y52 Phosphorylation HPRD   phospho.ELM   UniProt 15592455, 18083107, 20068231
T81 Phosphorylation HPRD 20068231
T83 Phosphorylation HPRD 20068231
Y89 Phosphorylation HPRD   phospho.ELM   UniProt 18083107, 20068231, 24275569
K92 Acetylation PRO   UniProt 18552846, 19818714
K92 Ubiquitination PRO   UniProt 19818714


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000045320 (hH4/InitMet-/Phos:1) pS2 PRO 15823538
PR:000045323 (hH4/InitMet-/Ac:1) acK17 PRO 15469825, 15765097, 15765097, ...18552846, 20479123, 20525793, 21272292
PR:000045325 (hH4/InitMet-/Ubiq:1) ubK92 PRO 19818714
PR:000045326 (hH4/InitMet-/Ac:2) acK92 PRO 18552846
PR:000045328 (hH4/InitMet-/Ac:3) acK13 PRO 10958685, 16387653, 18552846
PR:000045329 (hH4/InitMet-/Ac:4) acK6 PRO 16387653, 18552846, 21272292, ...8343956
PR:000045330 (hH4/InitMet-/Ac:5) acK9 PRO 10958685, 16387653, 18552846


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 C2 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K6 E6 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K17 N17 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K17 R17 Biomuta DOID:3571 / liver cancer [ cosmic ]
K21 R21 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K21 N21 Biomuta DOID:3571 / liver cancer [ cosmic ]
K21 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y52 C52 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T83 S83 Biomuta DOID:9256 / colorectal cancer [ cosmic ]