iPTMnet Report for P62195 (PSMC5)
Protein Information
UniProt AC / UniProt ID | P62195 / PRS8_HUMAN |
Protein Name | 26S proteasome regulatory subunit 8 |
Gene Name | Name: PSMC5 Synonyms:SUG1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P62195 |
PRO Name | 26S proteasome regulatory subunit 8 (human) |
Definition | A 26S proteasome regulatory subunit 8 that is encoded in the genome of human. |
Short Label | hPSMC5 |
Category | organism-gene |
P62195 (PSMC5) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
M1 | Acetylation | score1 | UniProt | 22814378 | ||
A2 | Acetylation | score1 | UniProt | 19413330, 25489052, 22814378, ... | ||
K15 | Ubiquitination | score1 | PhosphoSitePlus | |||
R21 | Methylation | score1 | PhosphoSitePlus | |||
Y24 | Phosphorylation | score1 | PhosphoSitePlus | |||
S26 | Phosphorylation | score1 | PhosphoSitePlus | |||
K27 | Ubiquitination | score1 | PhosphoSitePlus | |||
N36 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
K38 | Ubiquitination | score1 | PhosphoSitePlus | |||
K55 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y72 | Phosphorylation | score1 | PhosphoSitePlus | |||
K88 | Ubiquitination | score1 | PhosphoSitePlus | |||
K94 | Acetylation | score1 | PhosphoSitePlus | |||
K94 | Ubiquitination | score1 | PhosphoSitePlus | |||
K101 | Ubiquitination | score1 | PhosphoSitePlus | |||
T109 | Phosphorylation | score1 | PhosphoSitePlus | |||
C112 | Methylation | score1 | IEDB | 31844290 | ||
C112 | S-Nitrosylation | score0 | dbSNO | 26338901 | ||
S120 | Phosphorylation | P17612 (PRKACA) | score4 | PhosphoSitePlus UniProt | 17565987, 23186163, 23275441 | |
Y121 | Phosphorylation | score1 | PhosphoSitePlus | |||
K125 | Ubiquitination | score1 | PhosphoSitePlus | |||
K130 | Ubiquitination | score1 | PhosphoSitePlus | |||
S136 | Phosphorylation | score1 | PhosphoSitePlus | |||
K142 | Ubiquitination | score1 | PhosphoSitePlus | |||
T147 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y148 | Phosphorylation | score1 | PhosphoSitePlus | |||
K156 | Ubiquitination | score1 | PhosphoSitePlus | |||
K162 | Ubiquitination | score1 | PhosphoSitePlus | |||
K170 | Ubiquitination | score1 | PhosphoSitePlus | |||
K184 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y189 | Phosphorylation | score1 | PhosphoSitePlus | |||
K196 | Ubiquitination | score1 | PhosphoSitePlus | |||
T197 | Phosphorylation | score1 | PhosphoSitePlus | |||
C209 | Methylation | score1 | IEDB | 31844290 | ||
S217 | Phosphorylation | score1 | PhosphoSitePlus | |||
K222 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K222 | Ubiquitination | score1 | PhosphoSitePlus | |||
S244 | Phosphorylation | score1 | PhosphoSitePlus | |||
S256 | Phosphorylation | score1 | PhosphoSitePlus | |||
S257 | Phosphorylation | score1 | PhosphoSitePlus | |||
S263 | Phosphorylation | score1 | PhosphoSitePlus | |||
K287 | Ubiquitination | score1 | PhosphoSitePlus | |||
K290 | Ubiquitination | score1 | PhosphoSitePlus | |||
S303 | Phosphorylation | score1 | PhosphoSitePlus | |||
K314 | Ubiquitination | score1 | PhosphoSitePlus | |||
K330 | Ubiquitination | score1 | PhosphoSitePlus | |||
K346 | Ubiquitination | score1 | PhosphoSitePlus | |||
K360 | Ubiquitination | score1 | PhosphoSitePlus | |||
C363 | Methylation | score1 | IEDB | 31844290 | ||
T364 | Phosphorylation | score1 | PhosphoSitePlus | |||
K389 | Ubiquitination | score1 | PhosphoSitePlus | |||
K397 | Ubiquitination | score1 | PhosphoSitePlus | |||
K402 | Ubiquitination | score1 | PhosphoSitePlus | |||
K403 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K88 | N88 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
S120 | N120 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
K130 | Q130 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S136 | P136 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
K170 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S263 | Y263 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S303 | L303 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
K330 | N330 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
K330 | M330 | Biomuta | DOID:10283 / prostate cancer [ cosmic, icgc ] | |
K346 | R346 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
K397 | E397 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
K402 | N402 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] |