iPTMnet Report for P61158 (ACTR3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P61158 / ARP3_HUMAN
Protein Name Actin-related protein 3
Gene Name Name: ACTR3
Synonyms:ARP3;
Organism Homo sapiens (Human)

PRO ID PR:P61158
DAG View
PRO Name actin-related protein 3 (human)
Definition An actin-related protein 3 that is encoded in the genome of human.
Short Label hACTR3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P61158 (ACTR3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
C8 S-Nitrosylation dbSNO 2212679, 22126794
C12 S-Nitrosylation dbSNO 2212679, 22126794
Y16 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
K18 Ubiquitination PhosphoSitePlus
C34 Methylation IEDB 31844290
K38 Ubiquitination PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
K53 Acetylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus
Y109 Phosphorylation PhosphoSitePlus
T113 Phosphorylation PhosphoSitePlus
T119 Phosphorylation PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus
Y140 Phosphorylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
Y184 Phosphorylation PhosphoSitePlus
C189 Methylation IEDB 31844290
K191 Ubiquitination PhosphoSitePlus
T201 Phosphorylation PhosphoSitePlus
Y202 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
K225 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
Y231 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107, 15592455
S232 Phosphorylation PhosphoSitePlus
Y233 Phosphorylation PhosphoSitePlus
C235 Methylation IEDB 31844290
K240 Acetylation PhosphoSitePlus   UniProt 19608861
K240 Ubiquitination PhosphoSitePlus
K244 Acetylation PhosphoSitePlus   UniProt 19608861
K244 Ubiquitination PhosphoSitePlus
K251 Acetylation PhosphoSitePlus   UniProt 19608861
K251 Ubiquitination PhosphoSitePlus
K254 Acetylation PhosphoSitePlus   UniProt 19608861
K254 Ubiquitination PhosphoSitePlus
K264 Sumoylation PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
K348 Acetylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
Y400 Phosphorylation HPRD   PhosphoSitePlus 20068231
C408 Methylation IEDB 31844290
S418 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 G2 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K53 N53 Biomuta DOID:3571 / liver cancer [ cosmic ]
S152 F152 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y233 F233 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K251 T251 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K264 N264 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K265 E265 Biomuta DOID:363 / uterine cancer [ icgc ]
S268 C268 Biomuta DOID:1324 / lung cancer [ cosmic ]
S325 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K348 Q348 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K359 N359 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S418 L418 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]