iPTMnet Report for P61088 (UBE2N)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P61088 / UBE2N_HUMAN
Protein Name Ubiquitin-conjugating enzyme E2 N
Gene Name Name: UBE2N
Synonyms:BLU;
Organism Homo sapiens (Human)

PRO ID PR:P61088
DAG View
PRO Name ubiquitin-conjugating enzyme E2 N (human)
Definition A ubiquitin-conjugating enzyme E2 N that is encoded in the genome of human.
Short Label hUBE2N
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P61088 (UBE2N) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K10 Acetylation PhosphoSitePlus
K10 Ubiquitination PhosphoSitePlus
K24 Sumoylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
Y34 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
K53 Acetylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
K82 Acetylation PhosphoSitePlus   UniProt 19608861
K82 Ubiquitination PhosphoSitePlus
C87 S-Nitrosylation dbSNO 19483679, 22178444
K92 Acetylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K94 Acetylation PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
T139 Phosphorylation PhosphoSitePlus
R141 Methylation PhosphoSitePlus
T144 Phosphorylation PhosphoSitePlus
R145 Methylation PhosphoSitePlus
Y147 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K10 N10 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K10 M10 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K24 R24 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K74 E74 Biomuta DOID:1319 / brain cancer [ cosmic ]
T139 I139 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]