iPTMnet Report for P61073 (CXCR4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P61073 / CXCR4_HUMAN
Protein Name C-X-C chemokine receptor type 4
Gene Name Name: CXCR4
Organism Homo sapiens (Human)

PRO ID PR:P61073
DAG View
PRO Name C-X-C chemokine receptor type 4 (human)
Definition A C-X-C chemokine receptor type 4 that is encoded in the genome of human.
Short Label hCXCR4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P61073 (CXCR4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation RLIMS-P 20048153
N11 N-Glycosylation GlyGen   UniProt 10486146, 15183061, 9151832, ...10756055
Y12 Phosphorylation PhosphoSitePlus
S18 O-Glycosylation GlyGen   UniProt 12034737
S18 Phosphorylation PhosphoSitePlus
Y135 Phosphorylation PhosphoSitePlus
Y157 Phosphorylation PhosphoSitePlus
N176 N-Glycosylation GlyGen 10486146, 9151832
S178 Phosphorylation RLIMS-P 17056593
K310 Ubiquitination PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
T318 Phosphorylation PhosphoSitePlus
S319 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 18220336
S321 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 20048153
S324 Phosphorylation Q05655 (PRKCD) , P43250 (GRK6) IEDB   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 25775124, 27127886, ...33936100, 19116316, 20048153, 10521508
S325 Phosphorylation P43250 (GRK6) , Q05655 (PRKCD) IEDB   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 35494241, 23186163, 25775124, ...27127886, 33936100, 19116316, 20048153, 19687226, 10521508
K327 Ubiquitination PhosphoSitePlus
S330 Phosphorylation P43250 (GRK6) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19687226, 23734232, 20048153
K331 Ubiquitination PhosphoSitePlus   UniProt 28978524
K333 Ubiquitination PhosphoSitePlus
R334 Methylation PhosphoSitePlus
S338 Phosphorylation Q05655 (PRKCD) phospho.ELM   PhosphoSitePlus   Signor 10521508, 20048153
S339 Phosphorylation P34947 (GRK5) , P11309 (PIM1) , P43250 (GRK6) , Q05655 (PRKCD) IEDB   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 35494241, 16357147, 27245949, ...24632620, 25471741, 26075720, 32764981, 33936100, 29665227, 20048153, 22722314, 19687226, 10521508, 23817178, 22745793, 24659821, 30018141, 19002187, 30353642, 32733009, 25775124, 24023874
S341 Phosphorylation phospho.ELM   PhosphoSitePlus 20048153
T342 Phosphorylation PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus
S346 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983, 20048153
S347 Phosphorylation phospho.ELM   PhosphoSitePlus 20048153
S348 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 20048153
S351 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20048153
S352 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 20048153
Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation HPRD 20068231
Y7 Phosphorylation HPRD 20068231
S18 Phosphorylation HPRD 20068231
T318 Phosphorylation HPRD 19651622, 18767875, 17081983
S319 Phosphorylation HPRD 19651622, 18669648
S321 Phosphorylation HPRD 19651622, 17081983
S324 Phosphorylation HPRD 19651622, 17081983, 20068231
S325 Phosphorylation HPRD 19651622, 17081983, 20068231
S346 Phosphorylation HPRD 17081983
S348 Phosphorylation HPRD 18669648, 17081983, 20068231
S351 Phosphorylation HPRD 18669648
S352 Phosphorylation HPRD 18669648, 17081983
Site PTM Type PTM Enzyme Score Source PMID
T322 Phosphorylation HPRD 19651622, 18767875, 17081983
S323 Phosphorylation HPRD 19651622, 18669648
S325 Phosphorylation HPRD 19651622, 17081983
S328 Phosphorylation HPRD 19651622, 17081983, 20068231
S329 Phosphorylation HPRD 19651622, 17081983, 20068231
S350 Phosphorylation HPRD 17081983
S352 Phosphorylation HPRD 18669648, 17081983, 20068231
S355 Phosphorylation HPRD 18669648
S356 Phosphorylation HPRD 18669648, 17081983


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q14847 (LASP1) S146 P61073 (CXCR4) unknown eFIP 32075106


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N11 S11 Biomuta [ cosmic ]
Y12 H12 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S178 N178 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K310 E310 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S312 A312 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S312 F312 Biomuta DOID:1612 / breast cancer [ icgc ]
T318 A318 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S319 F319 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T322 A322 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S323 F323 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S324 F324 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S325 R325 Biomuta DOID:3571 / liver cancer [ cosmic ]
K327 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S328 F328 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S329 R329 Biomuta DOID:3571 / liver cancer [ cosmic ]
S330 C330 Biomuta DOID:1324 / lung cancer [ cosmic ]
S330 Y330 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K331 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K333 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R334 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
R334 Q334 Biomuta DOID:1324 / lung cancer [ cosmic ]
S338 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S338 A338 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S339 Y339 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S339 F339 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S347 L347 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S351 Y351 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ icgc ]
S355 Y355 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ icgc ]