iPTMnet Report for P60953 (CDC42)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P60953 / CDC42_HUMAN
Protein Name Cell division control protein 42 homolog precursor
Gene Name Name: CDC42
Organism Homo sapiens (Human)

PRO ID PR:P60953
DAG View
PRO Name cell division control protein 42 homolog (human)
Definition A cell division control protein 42 that is encoded in the genome of human.
Short Label hCDC42
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P60953 (CDC42) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Ubiquitination PhosphoSitePlus
C6 Methylation IEDB 31844290
S30 Phosphorylation PhosphoSitePlus
Y32 Phosphorylation PhosphoSitePlus
T35 O-Glycosylation UniProt 7775453, 24905543, 7777059, ...8810274
Y64 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14506284, 22163037
S71 Phosphorylation RLIMS-P 22970203, 22537182, 23071436
K96 Ubiquitination PhosphoSitePlus
C105 Methylation IEDB 31844290
K107 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
T141 Phosphorylation PhosphoSitePlus
K144 Acetylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K153 Acetylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
T161 Phosphorylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y32 Phosphorylation PhosphoSitePlus
T35 Phosphorylation PhosphoSitePlus
Y64 Phosphorylation P12931 (SRC) PhosphoSitePlus 14506284
K107 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
K135 Acetylation PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
K144 Acetylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
Y154 Phosphorylation PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P60953 (CDC42) Y64 P52565 (ARHGDIA) increased_association eFIP 22163037
Phosphorylation Q03135 (CAV1) Y14 P60953 (CDC42) unknown eFIP 21828338


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S30 L30 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K133 * Biomuta DOID:2531 / hematologic cancer [ cosmic, cosmic ]
K163 N163 Biomuta DOID:1324 / lung cancer [ cosmic ]
K166 N166 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K166 E166 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]