iPTMnet Report for P60891 (PRPS1)
Protein Information
UniProt AC / UniProt ID | P60891 / PRPS1_HUMAN |
Protein Name | Ribose-phosphate pyrophosphokinase 1 |
Gene Name | Name: PRPS1 |
Organism | Homo sapiens (Human) |
PRO ID | PR:P60891 |
PRO Name | ribose-phosphate pyrophosphokinase 1 (human) |
Definition | A ribose-phosphate pyrophosphokinase 1 that is encoded in the genome of human. |
Short Label | hPRPS1 |
Category | organism-gene |
P60891 (PRPS1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K5 | Ubiquitination | score1 | PhosphoSitePlus | |||
K18 | Ubiquitination | score1 | PhosphoSitePlus | |||
R22 | Methylation | score1 | PhosphoSitePlus | |||
K29 | Ubiquitination | score1 | PhosphoSitePlus | |||
S36 | Phosphorylation | score1 | PhosphoSitePlus | |||
S103 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 31253668 | ||
Y146 | Phosphorylation | score1 | PhosphoSitePlus | |||
R156 | Methylation | score1 | PhosphoSitePlus | |||
K176 | Acetylation | score1 | PhosphoSitePlus | |||
K176 | Ubiquitination | score1 | PhosphoSitePlus | |||
S180 | Phosphorylation | Q13131 (PRKAA1) | score3 | PhosphoSitePlus Signor | 29074724 | |
R184 | Methylation | score1 | PhosphoSitePlus | |||
K194 | Acetylation | score1 | PhosphoSitePlus | |||
K194 | Ubiquitination | score1 | PhosphoSitePlus | |||
R204 | Methylation | score1 | PhosphoSitePlus | |||
K212 | Acetylation | score1 | PhosphoSitePlus | |||
K212 | Ubiquitination | score1 | PhosphoSitePlus | |||
T225 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 27088854 | ||
T228 | Phosphorylation | score1 | PhosphoSitePlus | |||
K235 | Ubiquitination | score1 | PhosphoSitePlus | |||
S238 | Phosphorylation | score1 | PhosphoSitePlus | |||
T242 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y245 | Phosphorylation | score1 | PhosphoSitePlus | |||
K280 | Ubiquitination | score1 | PhosphoSitePlus | |||
S285 | Phosphorylation | score1 | PhosphoSitePlus | |||
S308 | Phosphorylation | score1 | PhosphoSitePlus | |||
S310 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y311 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
R22 | H22 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
S103 | I103 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
S103 | N103 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S103 | R103 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] | |
S103 | T103 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
R156 | M156 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
K176 | E176 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S180 | P180 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
S180 | Y180 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
R204 | C204 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] | |
R204 | L204 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S238 | L238 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
T242 | I242 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
K280 | R280 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] |