iPTMnet Report P60880 SNAP25

Protein Information

Cytoscape View

UniProt AC / UniProt ID	P60880 / SNP25_HUMAN
Protein Name	Synaptosomal-associated protein 25
Gene Name	Name: SNAP25 Synonyms:SNAP;
Organism	Homo sapiens (Human)

PRO ID	PR:P60880 DAG View
PRO Name	synaptosomal-associated protein 25 (human)
Definition	A synaptosomal-associated protein 25 that is encoded in the genome of human.
Short Label	hSNAP25
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P60880 (SNAP25) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S28	Phosphorylation		score1	PhosphoSitePlus
	T29	Phosphorylation		score1	PhosphoSitePlus
	K40	Ubiquitination		score1	PhosphoSitePlus
	K103	Ubiquitination		score1	PhosphoSitePlus
	S115	O-Glycosylation		score1	GlyGen	30379171, 36240223
	T138	Phosphorylation	P17252 (PRKCA)	score4	PhosphoSitePlus RLIMS-P Signor	22311984, 12459461, 17325194, ...14766180, 28486561
	S187	Phosphorylation	P17252 (PRKCA)	score4	PhosphoSitePlus RLIMS-P Signor	22311984, 12459461, 17325194, ...14529723, 18171919

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T138	Phosphorylation	P17612 (PRKACA) , P17252 (PRKCA)	score1	HPRD	12459461
	S187	Phosphorylation	P17252 (PRKCA)	score1	HPRD	12459461

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	K76	Acetylation		score1	PhosphoSitePlus
	K79	Ubiquitination		score1	PhosphoSitePlus
	T138	Phosphorylation	P17252 (PRKCA) , P17612 (PRKACA)	score1	HPRD	12459461
	S187	Phosphorylation	P17252 (PRKCA)	score1	HPRD	12459461

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S28	I28	Biomuta		DOID:363 / uterine cancer [ icgc ]
K40	T40	Biomuta		DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S115	R115	Biomuta		DOID:10534 / stomach cancer [ cosmic ]
S187	F187	Biomuta		DOID:4159 / skin cancer [ cosmic, icgc ]
S187	T187	Biomuta		DOID:1324 / lung cancer [ cosmic, icgc ]