iPTMnet Report for P59047 (NLRP5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P59047 / NALP5_HUMAN
Protein Name NACHT, LRR and PYD domains-containing protein 5
Gene Name Name: NLRP5
Synonyms:MATER;
Organism Homo sapiens (Human)

PRO ID PR:P59047
DAG View
PRO Name NACHT, LRR and PYD domains-containing protein 5 (human)
Definition A NACHT, LRR and PYD domains-containing protein 5 that is encoded in the genome of human.
Short Label hNLRP5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P59047 (NLRP5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation PhosphoSitePlus
R20 Methylation PhosphoSitePlus
T185 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
S331 Phosphorylation Q02156 (PRKCE) neXtProt   Signor 19542546
S642 Phosphorylation PhosphoSitePlus
S1062 Phosphorylation PhosphoSitePlus
S1064 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S16 * Biomuta DOID:1324 / lung cancer [ cosmic ]
R20 S20 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
R20 C20 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic ]
S191 L191 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S191 A191 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S331 C331 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S642 G642 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S642 N642 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1062 L1062 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic, icgc ]