iPTMnet Report for P58876 (H2BC5)
Protein Information
| UniProt AC / UniProt ID | P58876 / H2B1D_HUMAN |
| Protein Name | Histone H2B type 1-D |
| Gene Name | Name: H2BC5 Synonyms:H2BFB,HIRIP2,HIST1H2BD; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P58876 |
| PRO Name | histone H2B type 1-D (human) |
| Definition | A histone H2B type 1-D that is encoded in the genome of human. |
| Short Label | hH2BC5 |
| Category | organism-gene |
DAG ViewP58876 (H2BC5) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Acetylation | score1 | PRO | ||||
| M1 | Acetylation | score1 | PRO | |||
| K6 | Acetylation | score2 | PRO UniProt | 18552846, 19608861, 16283522, ... | ||
| K12 | Acetylation | score2 | PhosphoSitePlus UniProt | 16627869 | ||
| K13 | Acetylation | score2 | PRO UniProt | 18552846, 16627869, 20693536, ... | ||
| S15 | Phosphorylation | score2 | PRO UniProt | 12757711 | ||
| K16 | Acetylation | score2 | PRO PhosphoSitePlus UniProt | 16283522, 19883641, 16627869 | ||
| K17 | Acetylation | score2 | PRO UniProt | 20693536, 16627869 | ||
| K21 | Acetylation | score2 | PRO UniProt | 18552846, 16627869, 16283522 | ||
| K24 | Acetylation | score1 | PhosphoSitePlus | |||
| K35 | Ubiquitination | score1 | UniProt | 21726816 | ||
| K47 | Acetylation | score1 | PRO | 20693536 | ||
| K47 | Methylation | score1 | UniProt | 16627869 | ||
| T53 | O-Glycosylation | score1 | GlyGen | 34105348 | ||
| S56 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S57 | O-Glycosylation | score1 | GlyGen | 34105348 | ||
| K58 | Methylation | score1 | UniProt | 16627869 | ||
| S65 | O-Glycosylation | score3 | GlyGen | 21224338, 34019948, 34105348, ... | ||
| K109 | Methylation | score1 | UniProt | 16627869 | ||
| K121 | Acetylation | score1 | PRO | 18552846 | ||
| K121 | Ubiquitination | score2 | PRO UniProt | 18400894, 16307923, 16627869, ... |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000036258 (hHIST1H2BD/Ac:1) | acM1 | PRO | |||
| PR:000045046 (hHIST1H2BD/InitMet-/Ac:1) | acK13 | PRO | 16283522, 18552846, 20693536 | ||
| PR:000045047 (hHIST1H2BD/InitMet-/Phos:1) | pS15 | PRO | 12757711 | ||
| PR:000045048 (hHIST1H2BD/InitMet-/Ac:2) | acK21 | PRO | 16283522, 18552846 | ||
| PR:000045050 (hHIST1H2BD/InitMet-/Ubiq:1) | ubK121 | PRO | 16307923, 16713563, 18400894, ... | ||
| PR:000045051 (hHIST1H2BD/InitMet-/Ac:3) | acK17 | PRO | 20693536 | ||
| PR:000045052 (hHIST1H2BD/InitMet-/Ac:4) | acK6 | PRO | 18552846 | ||
| PR:000045054 (hHIST1H2BD/InitMet-/Ac:5) | acK47 | PRO | 20693536 | ||
| PR:000045055 (hHIST1H2BD/InitMet-/Ac:6) | acK121 | PRO | 18552846 | ||
| PR:000045056 (hHIST1H2BD/InitMet-/Ac:7) | acK16 | PRO | 19883641 | ||
| PR:000047773 (hHIST1H2BD/InitMet-/N6AcLys+) | ac | PRO |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K12 | Q12 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| K13 | * | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| K13 | N13 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| K35 | R35 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S56 | Y56 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S56 | C56 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S57 | F57 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| K121 | R121 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] |
