iPTMnet Report for P58107 (EPPK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P58107 / EPIPL_HUMAN
Protein Name Epiplakin
Gene Name Name: EPPK1
Synonyms:EPIPL;
Organism Homo sapiens (Human)

PRO ID PR:P58107
DAG View
PRO Name epiplakin (human)
Definition An epiplakin that is encoded in the genome of human.
Short Label hEPPK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P58107 (EPPK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T29 Phosphorylation PhosphoSitePlus
T34 Phosphorylation PhosphoSitePlus   UniProt 23186163
K97 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
Y280 Phosphorylation PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
K484 Sumoylation PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
S561 Phosphorylation PhosphoSitePlus
T568 Phosphorylation PhosphoSitePlus
K574 Ubiquitination PhosphoSitePlus
Y583 Phosphorylation PhosphoSitePlus
K660 Ubiquitination PhosphoSitePlus
S663 Phosphorylation PhosphoSitePlus
K680 Ubiquitination PhosphoSitePlus
T689 Phosphorylation PhosphoSitePlus
Y695 Phosphorylation PhosphoSitePlus
S701 Phosphorylation PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
T726 Phosphorylation PhosphoSitePlus
Y744 Phosphorylation PhosphoSitePlus
T777 Phosphorylation PhosphoSitePlus
Y778 Phosphorylation PhosphoSitePlus
T791 Phosphorylation PhosphoSitePlus
S799 Phosphorylation PhosphoSitePlus
K866 Ubiquitination PhosphoSitePlus
T872 Phosphorylation PhosphoSitePlus
Y998 Phosphorylation PhosphoSitePlus
K1018 Ubiquitination PhosphoSitePlus
S1021 Phosphorylation PhosphoSitePlus
K1028 Ubiquitination PhosphoSitePlus
C1102 S-Nitrosylation dbSNO 26338901
K1139 Ubiquitination PhosphoSitePlus
S1256 Phosphorylation PhosphoSitePlus
T1273 Phosphorylation PhosphoSitePlus
K1305 Ubiquitination PhosphoSitePlus
S1314 Phosphorylation PhosphoSitePlus
S1390 Phosphorylation PhosphoSitePlus
K1398 Ubiquitination PhosphoSitePlus
K1401 Ubiquitination PhosphoSitePlus
S1407 Phosphorylation PhosphoSitePlus
Y1414 Phosphorylation PhosphoSitePlus
T1506 Phosphorylation PhosphoSitePlus
S1529 Phosphorylation PhosphoSitePlus
K1542 Ubiquitination PhosphoSitePlus
T1543 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1548 Phosphorylation PhosphoSitePlus
T1551 Phosphorylation PhosphoSitePlus
S1562 Phosphorylation PhosphoSitePlus
K1564 Acetylation PhosphoSitePlus
K1564 Ubiquitination PhosphoSitePlus
K1622 Ubiquitination PhosphoSitePlus
T1624 O-Glycosylation GlyGen 23301498, 33214551, 26374642, ...33465208, 30397120
T1624 Phosphorylation PhosphoSitePlus
K1636 Ubiquitination PhosphoSitePlus
K1641 Ubiquitination PhosphoSitePlus
Y1656 Phosphorylation PhosphoSitePlus
S1662 Phosphorylation PhosphoSitePlus
K1669 Ubiquitination PhosphoSitePlus
Y1705 Phosphorylation PhosphoSitePlus
Y1709 Phosphorylation PhosphoSitePlus
S1722 Phosphorylation PhosphoSitePlus
T1725 Phosphorylation PhosphoSitePlus
K1726 Ubiquitination PhosphoSitePlus
T1738 Phosphorylation PhosphoSitePlus
Y1739 Phosphorylation PhosphoSitePlus
K1762 Ubiquitination PhosphoSitePlus
S1821 Phosphorylation PhosphoSitePlus
K1846 Ubiquitination PhosphoSitePlus
K1868 Ubiquitination PhosphoSitePlus
T1869 Phosphorylation PhosphoSitePlus
T1872 Phosphorylation PhosphoSitePlus
S1912 Phosphorylation PhosphoSitePlus
K2000 Ubiquitination PhosphoSitePlus
K2062 Ubiquitination PhosphoSitePlus
T2111 Phosphorylation PhosphoSitePlus
T2182 Phosphorylation PhosphoSitePlus
T2223 Phosphorylation PhosphoSitePlus
C2225 S-Nitrosylation dbSNO 26338901
K2234 Ubiquitination PhosphoSitePlus
K2242 Ubiquitination PhosphoSitePlus
S2244 Phosphorylation PhosphoSitePlus
K2299 Ubiquitination PhosphoSitePlus
Y2314 Phosphorylation PhosphoSitePlus
S2320 Phosphorylation PhosphoSitePlus
K2327 Ubiquitination PhosphoSitePlus
T2345 Phosphorylation PhosphoSitePlus
Y2363 Phosphorylation PhosphoSitePlus
Y2367 Phosphorylation PhosphoSitePlus
S2380 Phosphorylation PhosphoSitePlus
K2384 Ubiquitination PhosphoSitePlus
T2396 Phosphorylation PhosphoSitePlus
Y2397 Phosphorylation PhosphoSitePlus
T2410 Phosphorylation PhosphoSitePlus
Y2413 Phosphorylation PhosphoSitePlus
S2422 Phosphorylation PhosphoSitePlus   UniProt 20068231
S2428 Phosphorylation PhosphoSitePlus
S2444 Phosphorylation PhosphoSitePlus
S2508 Phosphorylation PhosphoSitePlus   UniProt 23186163, 17081983, 20068231
S2542 Phosphorylation PhosphoSitePlus
Y2544 Phosphorylation PhosphoSitePlus
S2546 Phosphorylation PhosphoSitePlus
T2572 Phosphorylation PhosphoSitePlus
R2603 Methylation PhosphoSitePlus
S2611 Phosphorylation PhosphoSitePlus
T2639 Phosphorylation PhosphoSitePlus
S2658 Phosphorylation PhosphoSitePlus
S2665 Phosphorylation PhosphoSitePlus
Y2667 Phosphorylation PhosphoSitePlus
K2707 Ubiquitination PhosphoSitePlus
S2709 Phosphorylation PhosphoSitePlus
S2718 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S2720 Phosphorylation PhosphoSitePlus
T2724 Phosphorylation PhosphoSitePlus
S2725 Phosphorylation PhosphoSitePlus
T2732 Phosphorylation PhosphoSitePlus
T2740 Phosphorylation PhosphoSitePlus
K2741 Ubiquitination PhosphoSitePlus
T2742 Phosphorylation PhosphoSitePlus
S2751 Phosphorylation PhosphoSitePlus
K2753 Ubiquitination PhosphoSitePlus
T2759 Phosphorylation PhosphoSitePlus
K2770 Ubiquitination PhosphoSitePlus
K2778 Ubiquitination PhosphoSitePlus
S2780 Phosphorylation PhosphoSitePlus
S2818 Phosphorylation PhosphoSitePlus
K2835 Ubiquitination PhosphoSitePlus
Y2850 Phosphorylation PhosphoSitePlus
S2856 Phosphorylation PhosphoSitePlus
K2863 Ubiquitination PhosphoSitePlus
T2881 Phosphorylation PhosphoSitePlus
Y2899 Phosphorylation PhosphoSitePlus
Y2903 Phosphorylation PhosphoSitePlus
S2916 Phosphorylation PhosphoSitePlus
K2920 Ubiquitination PhosphoSitePlus
T2932 Phosphorylation PhosphoSitePlus
Y2933 Phosphorylation PhosphoSitePlus
T2946 Phosphorylation PhosphoSitePlus
Y2949 Phosphorylation PhosphoSitePlus
S2958 Phosphorylation PhosphoSitePlus   UniProt 20068231
S2964 Phosphorylation PhosphoSitePlus
S2980 Phosphorylation PhosphoSitePlus
S3044 Phosphorylation PhosphoSitePlus   UniProt 23186163, 17081983, 20068231
S3082 Phosphorylation PhosphoSitePlus
T3108 Phosphorylation PhosphoSitePlus
R3139 Methylation PhosphoSitePlus
S3147 Phosphorylation PhosphoSitePlus
T3170 Phosphorylation PhosphoSitePlus
S3189 Phosphorylation PhosphoSitePlus
S3196 Phosphorylation PhosphoSitePlus
Y3198 Phosphorylation PhosphoSitePlus
K3238 Ubiquitination PhosphoSitePlus
S3240 Phosphorylation PhosphoSitePlus
S3249 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S3251 Phosphorylation PhosphoSitePlus
T3255 Phosphorylation PhosphoSitePlus
S3256 Phosphorylation PhosphoSitePlus
T3263 Phosphorylation PhosphoSitePlus
T3271 Phosphorylation PhosphoSitePlus
K3272 Ubiquitination PhosphoSitePlus
T3273 Phosphorylation PhosphoSitePlus
S3282 Phosphorylation PhosphoSitePlus
K3284 Ubiquitination PhosphoSitePlus
T3290 Phosphorylation PhosphoSitePlus
K3301 Ubiquitination PhosphoSitePlus
K3309 Ubiquitination PhosphoSitePlus
S3311 Phosphorylation PhosphoSitePlus
S3349 Phosphorylation PhosphoSitePlus
K3366 Ubiquitination PhosphoSitePlus
Y3381 Phosphorylation PhosphoSitePlus
S3387 Phosphorylation PhosphoSitePlus
K3394 Ubiquitination PhosphoSitePlus
T3412 Phosphorylation PhosphoSitePlus
Y3430 Phosphorylation PhosphoSitePlus
Y3434 Phosphorylation PhosphoSitePlus
S3447 Phosphorylation PhosphoSitePlus
K3451 Ubiquitination PhosphoSitePlus
T3463 Phosphorylation PhosphoSitePlus
Y3464 Phosphorylation PhosphoSitePlus
T3477 Phosphorylation PhosphoSitePlus
Y3480 Phosphorylation PhosphoSitePlus
S3489 Phosphorylation PhosphoSitePlus   UniProt 20068231
S3495 Phosphorylation PhosphoSitePlus
S3511 Phosphorylation PhosphoSitePlus
S3575 Phosphorylation PhosphoSitePlus   UniProt 23186163, 17081983, 20068231
S3613 Phosphorylation PhosphoSitePlus
T3639 Phosphorylation PhosphoSitePlus
R3670 Methylation PhosphoSitePlus
S3678 Phosphorylation PhosphoSitePlus
T3704 Phosphorylation PhosphoSitePlus
S3723 Phosphorylation PhosphoSitePlus
S3730 Phosphorylation PhosphoSitePlus
Y3732 Phosphorylation PhosphoSitePlus
K3772 Ubiquitination PhosphoSitePlus
S3774 Phosphorylation PhosphoSitePlus
S3783 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S3785 Phosphorylation PhosphoSitePlus
T3789 Phosphorylation PhosphoSitePlus
S3790 Phosphorylation PhosphoSitePlus
T3797 Phosphorylation PhosphoSitePlus
T3805 Phosphorylation PhosphoSitePlus
K3806 Ubiquitination PhosphoSitePlus
T3807 Phosphorylation PhosphoSitePlus
S3816 Phosphorylation PhosphoSitePlus
K3818 Ubiquitination PhosphoSitePlus
T3824 Phosphorylation PhosphoSitePlus
K3835 Ubiquitination PhosphoSitePlus
K3843 Ubiquitination PhosphoSitePlus
S3845 Phosphorylation PhosphoSitePlus
S3883 Phosphorylation PhosphoSitePlus
K3900 Ubiquitination PhosphoSitePlus
Y3915 Phosphorylation PhosphoSitePlus
S3921 Phosphorylation PhosphoSitePlus
K3928 Ubiquitination PhosphoSitePlus
T3946 Phosphorylation PhosphoSitePlus
Y3964 Phosphorylation PhosphoSitePlus
Y3968 Phosphorylation PhosphoSitePlus
S3981 Phosphorylation PhosphoSitePlus
K3985 Ubiquitination PhosphoSitePlus
T3997 Phosphorylation PhosphoSitePlus
Y3998 Phosphorylation PhosphoSitePlus
T4011 Phosphorylation PhosphoSitePlus
Y4014 Phosphorylation PhosphoSitePlus
S4023 Phosphorylation PhosphoSitePlus   UniProt 20068231
S4029 Phosphorylation PhosphoSitePlus
S4045 Phosphorylation PhosphoSitePlus
S4109 Phosphorylation PhosphoSitePlus   UniProt 23186163, 17081983, 20068231
S4143 Phosphorylation PhosphoSitePlus
Y4145 Phosphorylation PhosphoSitePlus
S4147 Phosphorylation PhosphoSitePlus
T4173 Phosphorylation PhosphoSitePlus
R4204 Methylation PhosphoSitePlus
T4238 Phosphorylation PhosphoSitePlus
S4257 Phosphorylation PhosphoSitePlus
S4264 Phosphorylation PhosphoSitePlus
Y4266 Phosphorylation PhosphoSitePlus
K4306 Ubiquitination PhosphoSitePlus
S4308 Phosphorylation PhosphoSitePlus
S4317 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S4319 Phosphorylation PhosphoSitePlus
T4323 Phosphorylation PhosphoSitePlus
S4324 Phosphorylation PhosphoSitePlus
T4331 Phosphorylation PhosphoSitePlus
T4339 Phosphorylation PhosphoSitePlus
K4340 Ubiquitination PhosphoSitePlus
T4341 Phosphorylation PhosphoSitePlus
S4350 Phosphorylation PhosphoSitePlus
K4352 Ubiquitination PhosphoSitePlus
T4358 Phosphorylation PhosphoSitePlus
K4369 Ubiquitination PhosphoSitePlus
K4377 Ubiquitination PhosphoSitePlus
S4379 Phosphorylation PhosphoSitePlus
S4417 Phosphorylation PhosphoSitePlus
K4434 Ubiquitination PhosphoSitePlus
Y4449 Phosphorylation PhosphoSitePlus
S4455 Phosphorylation PhosphoSitePlus
K4462 Ubiquitination PhosphoSitePlus
T4480 Phosphorylation PhosphoSitePlus
Y4498 Phosphorylation PhosphoSitePlus
Y4502 Phosphorylation PhosphoSitePlus
S4515 Phosphorylation PhosphoSitePlus
K4519 Ubiquitination PhosphoSitePlus
T4531 Phosphorylation PhosphoSitePlus
Y4532 Phosphorylation PhosphoSitePlus
T4545 Phosphorylation PhosphoSitePlus
Y4548 Phosphorylation PhosphoSitePlus
S4557 Phosphorylation PhosphoSitePlus   UniProt 20068231
S4563 Phosphorylation PhosphoSitePlus
S4579 Phosphorylation PhosphoSitePlus
S4645 Phosphorylation PhosphoSitePlus   UniProt 23186163, 17081983, 20068231
S4683 Phosphorylation PhosphoSitePlus
T4709 Phosphorylation PhosphoSitePlus
R4740 Methylation PhosphoSitePlus
S4748 Phosphorylation PhosphoSitePlus
T4771 Phosphorylation PhosphoSitePlus
S4790 Phosphorylation PhosphoSitePlus
S4797 Phosphorylation PhosphoSitePlus
Y4799 Phosphorylation PhosphoSitePlus
K4839 Ubiquitination PhosphoSitePlus
S4841 Phosphorylation PhosphoSitePlus
S4850 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S4852 Phosphorylation PhosphoSitePlus
T4856 Phosphorylation PhosphoSitePlus
S4857 Phosphorylation PhosphoSitePlus
T4864 Phosphorylation PhosphoSitePlus
T4872 Phosphorylation PhosphoSitePlus
K4873 Ubiquitination PhosphoSitePlus
T4874 Phosphorylation PhosphoSitePlus
S4883 Phosphorylation PhosphoSitePlus
K4885 Ubiquitination PhosphoSitePlus
T4891 Phosphorylation PhosphoSitePlus
K4902 Ubiquitination PhosphoSitePlus
K4910 Ubiquitination PhosphoSitePlus
S4912 Phosphorylation PhosphoSitePlus
S4950 Phosphorylation PhosphoSitePlus
K4967 Ubiquitination PhosphoSitePlus
Y4982 Phosphorylation PhosphoSitePlus
S4988 Phosphorylation PhosphoSitePlus
K4995 Ubiquitination PhosphoSitePlus
T5013 Phosphorylation PhosphoSitePlus
Y5031 Phosphorylation PhosphoSitePlus
Y5035 Phosphorylation PhosphoSitePlus
S5048 Phosphorylation PhosphoSitePlus
K5052 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T29 M29 Biomuta DOID:1319 / brain cancer [ cosmic ]
T34 M34 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
K139 N139 Biomuta DOID:3571 / liver cancer [ cosmic ]
K708 E708 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y744 C744 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T777 M777 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T791 M791 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
T872 M872 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S1021 P1021 Biomuta DOID:10283 / prostate cancer [ cosmic ]
C1102 Y1102 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
C1102 F1102 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
C1102 G1102 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1256 F1256 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K1398 R1398 Biomuta DOID:3571 / liver cancer [ cosmic ]
K1542 N1542 Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
T1543 M1543 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1622 R1622 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1622 * Biomuta DOID:3571 / liver cancer [ cosmic ]
C2225 G2225 Biomuta DOID:2021 / placenta cancer [ cosmic ]
K2299 R2299 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K2299 N2299 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
Y2314 H2314 Biomuta DOID:5158 / pleural cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
S2320 F2320 Biomuta DOID:4159 / skin cancer [ cosmic ]
T2345 K2345 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T2345 P2345 Biomuta DOID:1324 / lung cancer [ cosmic ]