iPTMnet Report for P56975 (NRG3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P56975 / NRG3_HUMAN
Protein Name Pro-neuregulin-3, membrane-bound isoform precursor
Gene Name Name: NRG3
Organism Homo sapiens (Human)

PRO ID PR:P56975
DAG View
PRO Name pro-neuregulin-3, membrane-bound isoform (human)
Definition A pro-neuregulin-3, membrane-bound isoform that is encoded in the genome of human.
Short Label hNRG3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P56975 (NRG3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S116 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
T156 Phosphorylation PhosphoSitePlus
S254 Phosphorylation PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
T276 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T277 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T278 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S280 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T281 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
Y357 Phosphorylation PhosphoSitePlus
Y405 Phosphorylation PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
T609 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T56 Phosphorylation PhosphoSitePlus
T60 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T56 M56 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S255 F255 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S256 Y256 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S256 F256 Biomuta DOID:1324 / lung cancer [ cosmic ]
S257 C257 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T276 R276 Biomuta DOID:1324 / lung cancer [ cosmic ]
T276 K276 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T276 M276 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
T277 M277 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S280 Y280 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y357 D357 Biomuta DOID:3571 / liver cancer [ cosmic ]
S410 F410 Biomuta DOID:4159 / skin cancer [ cosmic ]
S410 Y410 Biomuta DOID:1324 / lung cancer [ cosmic ]
T609 P609 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]