iPTMnet Report for P56545 (CTBP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P56545 / CTBP2_HUMAN
Protein Name C-terminal-binding protein 2
Gene Name Name: CTBP2
Organism Homo sapiens (Human)

PRO ID PR:P56545
DAG View
PRO Name C-terminal-binding protein 2 (human)
Definition A C-terminal-binding protein 2 that is encoded in the genome of human.
Short Label hCTBP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P56545 (CTBP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Acetylation PhosphoSitePlus
K8 Acetylation PhosphoSitePlus
K10 Acetylation PhosphoSitePlus
R22 Methylation PhosphoSitePlus   UniProt 24129315
R33 Methylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
Y108 Phosphorylation PhosphoSitePlus
C140 Methylation IEDB 31844290
S164 Phosphorylation PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
R291 Methylation PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
T414 Phosphorylation PhosphoSitePlus
S428 Phosphorylation Q9H2X6 (HIPK2) PhosphoSitePlus   UniProt 25659434, 24275569
Site PTM Type PTM Enzyme Score Source PMID
K6 Acetylation PR:000007102 (EP300) PRO 16356938
K8 Acetylation PR:000007102 (EP300) PRO 16356938
K10 Acetylation PR:000007102 (EP300) PRO 16356938
T84 Phosphorylation HPRD 20068231
T414 Phosphorylation HPRD 18669648
S428 Phosphorylation HPRD 18669648
T433 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S94 Phosphorylation PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
T179 Phosphorylation HPRD   PhosphoSitePlus 17525332
S181 Phosphorylation HPRD   PhosphoSitePlus 17525332
S185 Phosphorylation HPRD   PhosphoSitePlus 17525332
T196 Phosphorylation PhosphoSitePlus
Y198 Phosphorylation PhosphoSitePlus
Y257 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
Y270 Phosphorylation PhosphoSitePlus
T624 Phosphorylation HPRD 20068231
T954 Phosphorylation HPRD 18669648
S968 Phosphorylation HPRD 18669648
T973 Phosphorylation HPRD 18669648


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000028569 (hCTBP2/iso:1/Ac:1) acK6,acK8,acK10 PR:000007102 (EP300) PRO 16356938


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K8 * Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
R22 H22 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T84 N84 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K94 N94 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
Y108 F108 Biomuta DOID:5158 / pleural cancer [ cosmic ]
Y108 C108 Biomuta DOID:3565 / meningioma [ cosmic ]
C140 G140 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S164 N164 Biomuta DOID:1612 / breast cancer [ cosmic ]
T179 I179 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y270 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K279 R279 Biomuta DOID:1612 / breast cancer [ cosmic ]
R291 P291 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R291 Q291 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
T433 S433 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T624 N624 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T973 S973 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]