iPTMnet Report for P56537 (EIF6)
Protein Information
| UniProt AC / UniProt ID | P56537 / IF6_HUMAN |
| Protein Name | Eukaryotic translation initiation factor 6 |
| Gene Name | Name: EIF6 Synonyms:EIF3A,ITGB4BP;ORFNames:OK/SW-cl.27; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P56537 |
| PRO Name | eukaryotic translation initiation factor 6 (human) |
| Definition | A eukaryotic translation initiation factor 6 that is encoded in the genome of human. |
| Short Label | hEIF6 |
| Category | organism-gene |
P56537 (EIF6) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S6 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C11 | S-Nitrosylation | score0 | dbSNO | 22178444 | ||
| C15 | S-Nitrosylation | score0 | dbSNO | 22178444 | ||
| C56 | Methylation | score1 | IEDB | 31844290 | ||
| R85 | Methylation | score1 | PhosphoSitePlus | |||
| R95 | Methylation | score1 | PhosphoSitePlus | |||
| Y113 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 15592455 | ||
| S150 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S174 | Phosphorylation | P48729 (CSNK1A1) | score4 | PhosphoSitePlus RLIMS-P UniProt | 12917340, 21084295 | |
| S175 | Phosphorylation | P48729 (CSNK1A1) | score4 | PhosphoSitePlus RLIMS-P UniProt | 12917340, 21084295 | |
| T185 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K223 | Acetylation | score1 | PhosphoSitePlus | |||
| S230 | O-Glycosylation | score1 | GlyGen | 23301498, 35008409, 33214551, ... | ||
| S230 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| T231 | O-Glycosylation | score1 | GlyGen | 31373491 | ||
| T231 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T234 | O-Glycosylation | score1 | GlyGen | 31373491 | ||
| T234 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S235 | O-Glycosylation | score1 | GlyGen | 31373491 | ||
| S235 | Phosphorylation | P17252 (PRKCA) , P05771 (PRKCB) | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor UniProt | 14654845, 18669648, 21665150 | |
| S239 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 20068231 | ||
| S243 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
| T245 | Phosphorylation | score1 | PhosphoSitePlus |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| Y113 | Phosphorylation | score0 | HPRD | 15592455 | ||
| S175 | Phosphorylation | score0 | HPRD | 18452278 | ||
| S230 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| T234 | Phosphorylation | P05771 (PRKCB) | score1 | HPRD | 14654845 | |
| S235 | Phosphorylation | score0 | HPRD | 18669648, 19007248, 20068231 | ||
| S239 | Phosphorylation | score0 | HPRD | 18669648, 19007248, 20068231 | ||
| S243 | Phosphorylation | score0 | HPRD | 18669648, 19007248, 20068231 | ||
| T245 | Phosphorylation | score0 | HPRD | 19007248 |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S40 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K54 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S156 | Phosphorylation | score0 | HPRD | 18452278 | ||
| S211 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| T215 | Phosphorylation | P05771 (PRKCB) | score1 | HPRD | 14654845 | |
| S216 | Phosphorylation | score0 | HPRD | 18669648, 19007248, 20068231 | ||
| S220 | Phosphorylation | score0 | HPRD | 18669648, 19007248, 20068231 | ||
| S224 | Phosphorylation | score0 | HPRD | 18669648, 19007248, 20068231 | ||
| T226 | Phosphorylation | score0 | HPRD | 19007248 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S6 | L6 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S40 | G40 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| K54 | T54 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| R85 | H85 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] | |
| S156 | F156 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S175 | F175 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| T185 | S185 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| T185 | I185 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
DAG View