iPTMnet Report for P56524 (HDAC4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P56524 / HDAC4_HUMAN
Protein Name Histone deacetylase 4
Gene Name Name: HDAC4
Synonyms:KIAA0288;
Organism Homo sapiens (Human)

PRO ID PR:P56524
DAG View
PRO Name histone deacetylase 4 (human)
Definition A histone deacetylase 4 that is encoded in the genome of human.
Short Label hHDAC4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P56524 (HDAC4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 O-Glycosylation GlyGen 30379171
S5 O-Glycosylation GlyGen 30379171
T36 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
S210 Phosphorylation Q13557 (CAMK2D) neXtProt   PhosphoSitePlus   Signor 17179159, 22360269
S215 Phosphorylation PhosphoSitePlus
Y225 Phosphorylation PhosphoSitePlus
Y233 Phosphorylation PhosphoSitePlus
K236 Acetylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
S246 Phosphorylation P57059 (SIK1) , O43318 (MAP3K7) , Q7KZI7 (MARK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 24934156, 26305553, 16980613, ...28319066, 27759007, 10869435, 17468767, 27807598, 10958686
S265 Phosphorylation Q96GD4 (AURKB) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 30661366, 22865920
S266 Phosphorylation IEDB   PhosphoSitePlus   RLIMS-P 32387766, 30661366
T278 Phosphorylation PhosphoSitePlus
S298 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   RLIMS-P   Signor 21118993
S302 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   RLIMS-P   Signor 21118993
S339 Phosphorylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus   UniProt 19690332, 22649097
T391 Phosphorylation PhosphoSitePlus
T394 Phosphorylation PhosphoSitePlus
S400 Phosphorylation PhosphoSitePlus
T465 Phosphorylation PhosphoSitePlus
S467 Phosphorylation P57059 (SIK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11470791, 26305553, 25728750, ...17468767, 18669648, 10958686
K494 Ubiquitination PhosphoSitePlus
Y540 Phosphorylation PhosphoSitePlus
K548 Acetylation PhosphoSitePlus
K559 Sumoylation PhosphoSitePlus
S565 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S584 Phosphorylation PhosphoSitePlus   RLIMS-P 30661366
S611 Phosphorylation PhosphoSitePlus
S632 Phosphorylation Q13557 (CAMK2D) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11470791, 22042619, 26305553, ...23186163, 17179159, 32818796, 22360269, 18669648, 24275569, 10958686
S633 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 22042619, 18669648
S636 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T638 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S642 O-Glycosylation GlyGen 29485866, 30379171, 31195810
S642 Phosphorylation PhosphoSitePlus   RLIMS-P 22042619
T648 Phosphorylation PhosphoSitePlus
K705 Ubiquitination PhosphoSitePlus
K737 Ubiquitination PhosphoSitePlus
S741 Phosphorylation PhosphoSitePlus
S744 Phosphorylation PhosphoSitePlus
S1025 Phosphorylation PhosphoSitePlus
K1026 Ubiquitination PhosphoSitePlus
T1057 Phosphorylation PhosphoSitePlus
S1061 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S210 Phosphorylation PR:Q13557-3 (hCAMK2D/iso:hDelta 3) PRO 17179159
S246 Phosphorylation PR:Q13557-3 (hCAMK2D/iso:hDelta 3) HPRD   PRO 17179159, 10869435, 10958686, ...20068231
S265 Phosphorylation HPRD 20068231
S266 Phosphorylation HPRD 20068231
T278 Phosphorylation HPRD 18491316
S467 Phosphorylation Q16566 (CAMK4) HPRD 11470791, 18669648
S565 Phosphorylation HPRD 19651622, 18669648, 20068231
S632 Phosphorylation Q16566 (CAMK4) HPRD 11470791, 19651622, 18669648, ...20068231
S633 Phosphorylation HPRD 18669648
S636 Phosphorylation HPRD 18669648
T638 Phosphorylation HPRD 18669648


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000029002 (hHDAC4/iso:1/Phos:1) pS210,pS246 PR:Q13557-3 (hCAMK2D/iso:hDelta 3) PRO 17179159


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P56524 (HDAC4) S246 P27348 (YWHAQ) unknown eFIP 33537682
Phosphorylation P56524 (HDAC4) S246 Q96RE7 (NACC1) unknown eFIP 28319066
Phosphorylation P56524 (HDAC4) S632 Q60929 (Mef2a) inhibited_association eFIP 32818796


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000029002 (hHDAC4/iso:1/Phos:1) Interaction PRO 17179159