iPTMnet Report for P56373 (P2RX3)
Protein Information
UniProt AC / UniProt ID | P56373 / P2RX3_HUMAN |
Protein Name | P2X purinoceptor 3 |
Gene Name | Name: P2RX3 |
Organism | Homo sapiens (Human) |
PRO ID | PR:P56373 |
PRO Name | P2X purinoceptor 3 (human) |
Definition | A P2X purinoceptor 3 that is encoded in the genome of human. |
Short Label | hP2RX3 |
Category | organism-gene |
P56373 (P2RX3) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T134 | Phosphorylation | score1 | PhosphoSitePlus | |||
N139 | N-Glycosylation | score4 | GlyGen UniProt | 27626375, 21186285 | ||
N170 | N-Glycosylation | score4 | GlyGen UniProt | 27626375, 21186285 | ||
K176 | Ubiquitination | score1 | PhosphoSitePlus | |||
S178 | Phosphorylation | score1 | PhosphoSitePlus | |||
N194 | N-Glycosylation | score4 | GlyGen UniProt | 27626375, 21186285 | ||
T196 | Phosphorylation | score1 | PhosphoSitePlus | |||
S269 | Phosphorylation | score1 | PhosphoSitePlus | |||
N290 | N-Glycosylation | score4 | GlyGen UniProt | 27626375, 21186285 | ||
T388 | Phosphorylation | score0 | RLIMS-P | 24755854 |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | P56373 (P2RX3) | T388 | Q03135 (CAV1) | increased_association | eFIP | 24755854 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
N139 | S139 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
S178 | N178 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
N194 | I194 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
T388 | S388 | Biomuta | DOID:1324 / lung cancer [ cosmic ] |