iPTMnet Report for P55795 (HNRNPH2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P55795 / HNRH2_HUMAN
Protein Name Heterogeneous nuclear ribonucleoprotein H2
Gene Name Name: HNRNPH2
Synonyms:FTP3,HNRPH2;
Organism Homo sapiens (Human)

PRO ID PR:P55795
DAG View
PRO Name heterogeneous nuclear ribonucleoprotein H2 (human)
Definition A heterogeneous nuclear ribonucleoprotein H2 that is encoded in the genome of human.
Short Label hHNRNPH2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P55795 (HNRNPH2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378, 22223895
S4 Phosphorylation PhosphoSitePlus
K14 Sumoylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
K35 Sumoylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
K72 Sumoylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
R81 Methylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
K98 Methylation PhosphoSitePlus
K98 Sumoylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
T100 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20166139
S104 Phosphorylation P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus 18691976, 17287340, 18220336, ...18847512, 18452278, 19651622, 14729942, 20166139
T107 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 20166139, 17287340
R114 Methylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
K167 Acetylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
Y180 Phosphorylation PhosphoSitePlus
K185 Acetylation PhosphoSitePlus
K185 Methylation PhosphoSitePlus
K185 Sumoylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
T193 Phosphorylation PhosphoSitePlus
Y195 Phosphorylation PhosphoSitePlus
R199 Methylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
R206 Methylation PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
R212 Methylation PhosphoSitePlus
R217 Methylation PhosphoSitePlus
Y219 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
R224 Methylation PhosphoSitePlus
R230 Methylation PhosphoSitePlus
R232 Methylation PhosphoSitePlus
R233 Methylation PhosphoSitePlus   UniProt 24129315
Y236 Phosphorylation HPRD   PhosphoSitePlus 15592455
Y240 Phosphorylation HPRD   PhosphoSitePlus 15592455
Y243 Phosphorylation PhosphoSitePlus
Y246 Phosphorylation HPRD   PhosphoSitePlus 15592455
Y249 Phosphorylation HPRD   PhosphoSitePlus 15592455
Y253 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
R259 Methylation PhosphoSitePlus
Y266 Phosphorylation PhosphoSitePlus
S269 O-Glycosylation GlyGen 23301498, 30397120, 34725712, ...34019948, 35132862, 28510447, 22121020, 34229054
S269 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
R294 Methylation PhosphoSitePlus
Y298 Phosphorylation PhosphoSitePlus
Y306 Phosphorylation PhosphoSitePlus
S310 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 18452278, ...18669648, 19690332, 20068231
K349 Ubiquitination PhosphoSitePlus
Y376 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 I4 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K14 R14 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T100 R100 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S104 N104 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R114 L114 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S161 L161 Biomuta DOID:4159 / skin cancer [ cosmic ]
K167 N167 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K170 N170 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y180 * Biomuta DOID:2021 / placenta cancer [ cosmic ]
K185 N185 Biomuta DOID:1324 / lung cancer [ cosmic ]
R199 Q199 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R199 * Biomuta DOID:363 / uterine cancer [ cosmic ]
R206 Q206 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
R206 W206 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y210 C210 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
Y210 F210 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y210 S210 Biomuta DOID:1324 / lung cancer [ cosmic ]
R217 I217 Biomuta DOID:1319 / brain cancer [ icgc ] DOID:1324 / lung cancer [ cosmic ]
Y243 C243 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y246 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y266 D266 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S269 L269 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S272 A272 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y298 H298 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S441 Y441 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]