iPTMnet Report for P54819 (AK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P54819 / KAD2_HUMAN
Protein Name Adenylate kinase 2, mitochondrial
Gene Name Name: AK2
Synonyms:ADK2;
Organism Homo sapiens (Human)

PRO ID PR:P54819
DAG View
PRO Name adenylate kinase 2, mitochondrial (human)
Definition An adenylate kinase 2, mitochondrial that is encoded in the genome of human.
Short Label hAK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P54819 (AK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378, 25944712
S4 O-Glycosylation GlyGen 23301498, 16408927, 35083852, ...30379171
S4 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y12 Phosphorylation PhosphoSitePlus
K14 Acetylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
K28 Acetylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
C40 S-Nitrosylation dbSNO 24105792
C42 S-Nitrosylation dbSNO 25040305, 24105792
T46 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus   UniProt 23186163
K62 Ubiquitination PhosphoSitePlus
K72 Acetylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
T89 Phosphorylation PhosphoSitePlus
C92 S-Nitrosylation dbSNO 19483679, 24105792
K93 Acetylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus   UniProt 24275569
K147 Ubiquitination PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
Y152 Phosphorylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
K181 Acetylation PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
T192 Phosphorylation PhosphoSitePlus
T194 Phosphorylation PhosphoSitePlus
T195 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y200 Phosphorylation PhosphoSitePlus
Y201 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
T215 Phosphorylation PhosphoSitePlus
C232 Methylation IEDB 31844290
C232 S-Nitrosylation dbSNO 24105792
K233 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S56 Phosphorylation HPRD 20068231
S208 Phosphorylation HPRD 20068231
T215 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S56 Phosphorylation HPRD 20068231
S208 Phosphorylation HPRD 20068231
T215 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S208 F208 Biomuta DOID:4159 / skin cancer [ cosmic ]